HAART对血清中可溶性白介素-2受体水平的影响  

The effect of HAART to serum soluble interleukin-2 receptors in AIDS patients

作　　者：孙桂珍[1] 张洪海[1] 张彤[1] 

机构地区：[1]首都医科大学附属北京佑安医院临床检验中心,100069

出　　处：《中华实验和临床病毒学杂志》2008年第3期219-221,共3页Chinese Journal of Experimental and Clinical Virology

摘　　要：目的 探讨高效抗逆转录病毒治疗（HAART）对血清中可溶性白介素-2受体（slL-2R）水平的影响。方法 收集90例接受HAART前后AIDS患者的血清和抗凝全血，用酶联免疫吸附试验（ELISA）检测血清sIL-2R水平，用流式细胞术检测患者外周血T淋巴细胞亚群计数，利用bDNA定量法检测病毒载量（VL）。结果 HAART治疗前sIL-2R平均水平为（3154±905）pg／ml，治疗后平均水平降至（2216±884）pg／ml（P〈0．001）。治疗后HAART无效组sIL-2R平均为（2846±963）pg／ml，有效组平均为（1879±875）pg／ml（P〈0．001）。结论 有效的HAART明显降低血清中sIL-2R水平，且sIL-2R水平具有一定的疗效判断作用。Objective To approach the effect of HAART to serum soluble interleukin-2 receptors in AIDS patients. Methods 90 cases of AIDS patients were chosen for detection of their slL-2R levels by enzyme-linked immunosorbent assay （ELISA）, peripheral blood CD4^＋ T cell counts by flow cytometry and viral load by Branch DNA amplification. Results The sIL-2R levels were （3154±905）pg/ml before HAART and （2216±884）pg/ml after（ P 〈 0.001 ）, After HAART, the sIL-2R levels were（2846±963） pg/ml in ineffective HAART group and （1879±875）pg/ml in effective HAART group （P 〈 0.001 ）. Conclusion The serum sIL-2R levels of AIDS patients were lowered by effective HAART, and it could judge the efficacy of HAART in same extent.

关 键 词：获得性免疫缺陷综合征 受体 白细胞介素-2 酶联免疫吸附测定 

分 类 号：R512.91[医药卫生—内科学]