成年期甲状腺功能减退对雄性小鼠海马神经颗粒素表达的影响  

Effect of adult-onset hypothyroidism on neurogranin expression in hippocampus of adult male mice

作　　者：曾宪忠[1,4] 朱德发[1] 陈贵海[2] 马维青[3] 

机构地区：[1]安徽医科大学第一附属医院老年内分泌科,安徽省老年病研究所,合肥230022 [2]安徽医科大学第一附属医院神经内科 [3]合肥市第一人民医院内分泌科 [4]江西省赣州市人民医院内分泌科

出　　处：《中华内分泌代谢杂志》2007年第6期519-520,共2页Chinese Journal of Endocrinology and Metabolism

基　　金：安徽省自然科学基金(03043708)

摘　　要：成年雄性昆明种小鼠分为对照组、丙基硫氧嘧啶(PTU)组、PTU+T_4组,造模8周后,免疫组化和Western印迹法检测神经颗粒素(Ng)表达,发现甲状腺功能减退(甲减)小鼠海马区Ng表达降低,用T_4治疗可使之恢复,提示海马内Ng减少可能是成年期甲减雄性小鼠认知功能受损的机制之一。Adult male Kunming mice were divided into normal control group, propylthiouracil （PTU） treated group and PTU ＋ T4 treated group. Neurogranin （Ng） protein expression in the hippocampus after 8 weeks was assayed by Western blotting and immunohistochemical method. Results showed that Ng protein was decreased in the hippocampus of male mice with adult-onset hypothyroidism, suggesting that decreased Ng, which is correctable by T4, is involved in cognitive dysfunction in adult-onset hypothyroid male mice.

关 键 词：甲状腺功能减退症 神经颗粒素 成年 小鼠 

分 类 号：R581.2[医药卫生—内分泌] R338[医药卫生—内科学]