日本大耳白兔红细胞调控淋巴细胞和NK细胞活性研究  

Effects of Japanese Giant Ear Red Blood Cells on Lymphocyte Proliferation and NK Cell Activity

作　　者：蔡月琴[1] 陈民利[1] 潘永明[1] 徐剑钦[1] 屠珏[1] 陈亮[1] 冷晓霞[1] 

机构地区：[1]浙江中医药大学动物实验研究中心/比较医学研究中心,杭州310053

出　　处：《中国养兔》2008年第5期39-41,26,共4页Chinese Journal of Rabbit Farming

基　　金：浙江省卫生厅项目(2007B153);浙江中医药大学校级科研基金(17106003)

摘　　要：应用红细胞促淋巴细胞转化和促NK细胞活性试验,对不同生理发育时期日本大耳白兔红细胞调控淋巴细胞和NK细胞活性进行研究。结果表明:青年组日本大耳白兔红细胞调控淋巴细胞能力明显高于幼年兔和老年兔(P<0.01);老年组红细胞调控NK活性能力明显高于青年组和幼年组(P<0.01),青年组高于幼年组(P<0.01)。日本大耳白兔红细胞调控淋巴细胞能力在青年时期达到了高峰,随后逐渐降低;而红细胞调控NK活性随年龄增长而显著增强,这提示老年兔的免疫活性细胞较多地处于预激活状态,并对刺激显示良好的免疫应答能力。To observe the effects of Japanese Giant Ear red blood cells （RBC） on lymphocyte proliferation and NK cell activity at different growing periods, lymphocyte transformation test and NK Cell Activity test were applied to analysize the effect of RBC on regulating the activity of lymphocyte and NK cells. The results showed that the index of lymphocyte proliferation in youth group was significantly higher than that in infant group and senile group （P〈0.01）. The activity of NK Cell in youth group was significantly lower than that in senile group, but higher than that in infant group （P〈0.01）. The effect of Japanese Giant Ear red blood cells （RBC） on lymphocyte proliferation was the highest at youth period, and was inhibited with increasing age. The activity of NK cell was regulated significantly with increasing age. All the results show that most of the immune competent cells in senile group were in pre-activated status.

关 键 词：日本大耳白兔 红细胞 淋巴细胞 NK细胞 

分 类 号：S829.1[农业科学—畜牧学]