盐酸雷尼替丁口腔速溶片的制备及质量检查  

Preparation and Quality Inspection of Ranitidine Hydrochloride Fast Dissolving Tablets

作　　者：牟微[1] 武玉洁 曹德英[1] 高岩磊[3] 刘树彬[3] 任蕾[3] 

机构地区：[1]河北医科大学药学院,河北石家庄050017 [2]河北柏齐药业有限公司,河北石家庄052165 [3]石家庄学院化工学院,河北石家庄050035

出　　处：《河北化工》2008年第7期38-39,56,共3页Hebei Chemical Industry

摘　　要：采用紫外分光光度法在314nm处测定盐酸雷尼替丁的含量及溶出度。盐酸雷尼替丁检测浓度在4～16μg/mL范围内与吸收度呈线性关系(r=0.9994,n=5),日内、日间精密度分别为0.88%、1.16%,平均回收率为99.59%,RSD=0.22%。该制剂制备工艺简单易行,质量检查方法准确可靠。The content of ranitidine hydrochloride was determined by UV-spectrophotometry at the wavelength of 314 nm. The detected concentration of ranitidine hydrochloride was in linear relation to absorptivity in the range of 4-16 μg/mL （r=0. 999 4,n=5）. The intra-day and inter-day precision were 0.88% and 1.16% .The average recovery was 99. 59% （RSD=0.22%）.The preparation of technique is simple and the method for quality inspection is accurate and reliable.

关 键 词：盐酸雷尼替丁 制备 质量检查 

分 类 号：R944.4[医药卫生—药剂学]