碘普罗胺过敏试验对其不良反应的预测价值  

Predictive Value of Iopromide Allergic Test for Its Adverse Reaction

作　　者：刘翠华[1] 

机构地区：[1]河北省邢台市人民医院内一科,054031

出　　处：《中国全科医学》2008年第13期1186-1187,共2页Chinese General Practice

摘　　要：目的探讨非离子型造影剂碘普罗胺过敏试验对其不良反应的预测价值。方法将进行介入检查/治疗的2032例患者随机分为两组,一组应用碘普罗胺1ml静脉注射进行过敏试验,判断不良反应,不论结果阳性或阴性均在备好抢救物品及严密监测下进行操作。另一组不进行过敏试验,直接在备好抢救物品及严密监测下进行操作。结果过敏试验组过敏试验阳性率为3.25%,不良反应的发生率为0.49%,非过敏试验组不良反应的发生率为0.59%,两组间差异无统计学意义(P>0.05)。过敏试验组5例出现中度不良反应,1例表现为局部荨麻疹,4例出现轻度不良反应,表现为打喷嚏,咳嗽。其中2例为过敏试验阴性患者。非过敏试验组6例出现轻度不良反应,2例表现恶心,呕吐;3例为打喷嚏,咳嗽;1例为唇、舌麻木感。结论碘普罗胺过敏试验对其不良反应无明显预测价值,应用造影剂的过程中应严密观察有无不良反应的发生,并及时做出相应的处理。Objective To explore the significance of the Iopromide allergic test to predict its adverse reaction. Methods Totally2032 patients receiving interventional diagnosis/therapy were divided into two groups at random, the patients in the trial group received intravenous injection of 1 ml ultravis for sensitive test to judge the adverse reaction, and close monitoring and preparing for emergency treatment were conducted. The patients in the other group did not receive the sensitive test, Results The positive rate was 3. 25% and the incidence of adverse reaction was 0. 49% in allergic test group. The incidence of adverse reaction was 0. 59% in non-allergic test group. No obvious difference was shown between the two groups （P〉0.05）. In the allergic test group, five cases presented moderate adverse reaction, of which one had local urticaria, and four had mild adverse reaction such as sneezing and coughing; and two cases had a negative allergic test. In the non-allergic test group, six cases presented mild adverse reaction, of which two presented nausea and vomiting, three presented sneezing and coughing, one presented numbness of lips and tongue. Conclusion Iopromide allergic test had no obvious significance to predict its adverse reaction. So we should monitor closely the occurrence of adverse reaction and deal with it promptly in the process of applying Iopromide.

关 键 词：造影剂 副作用 预测 

分 类 号：R981.1[医药卫生—药品]