Ge-132对荷瘤小鼠NK细胞活性及红细胞免疫功能的影响  

THE EFFECT OF Ge-132 ON NK CELL ACTIVITY AND RED CELL IMMUNE FUNCTION IN TUMOR-BEARING MICE

作　　者：司传平[1] 于江[1] 朱怀甫[1] 上官国强[1] 刘宁[1] 党锡连[1] 

机构地区：[1]济宁医学院免疫学教研室

出　　处：《济宁医学院学报》1997年第1期25-27,共3页Journal of Jining Medical University

摘　　要：为了探讨Ｇｅ－１３２抗癌作用机制，本文进行了Ｇｅ－１３２对荷瘤小鼠脾脏ＮＫ细胞活性和红细胞免疫粘附功能影响的体内实验研究。实验采用Ｃ５７ＢＬ／６荷瘤小鼠，腹腔注射Ｇｅ－１３２（剂量分别为１００ｍｇ／ｋｇ、３００ｍｇ／ｋｇ），每日１次，连续１４天后，取小鼠脾细胞和血液进行ＮＫ细胞活性及红细胞免疫粘附功能测定，并摘除瘤块称重，计算抑瘤率。结果表明，Ｇｅ－１３２对小鼠抑植瘤（Ｓ１８０）的生长具有显著的抑制效应，抑瘤率达５５％；荷瘤小鼠脾细胞ＮＫ活性明显低于正常对照组，Ｇｅ－１３２能使其得以恢复；荷瘤小鼠ＲＢＣ－Ｃ３ｂ受体花环率和肿瘤ＲＢＣ花环率明显低于正常对照组（Ｐ＜００１），ＲＢＣ－ＩＣ花环率则高于正常对照组（Ｐ＜００１），注射Ｇｅ－１３２可显著提高ＲＢＣ－Ｃ３ｂ受体花环率和肿瘤ＲＢＣ花环率，降低ＲＢＣ－ＩＣ花环率。表明Ｇｅ－１３２能增强荷瘤小鼠ＮＫ细胞杀伤活性和红细胞免疫粘附功能。In the present study it was observed that the in vivo effect of Ge-132 on NK cell activity and red cell immune function in tumor bearing mice.The results showed that Ge-132 could inhibit significantly the growth of the tumor in the tumor bearing mice.The activity of NK cells and the levels of RBC C 3b receptor rosette forming rate(RBC-C 3bRR) and RBC tumor rosette forming rate(RBC-TR) in tumor bearing mice were lower significantly than those in normal control group (P<0 01).However,the RBC immune complex rosette forming rate(RBC-ICR) was higher in tumor bearing mice than that in normal control group(P<0 01).Ge-132 could enhance NK activity and increase RC 3bRR and RBC-TR and decrease RICR of tumor bearing mice compared with tumor control group.The results indicated that Ge-132 could signficantly enhance the activity of NK cells and the red cell immune function in tumor bearing mice.The anti cancer effect of Ge-132 may be mediated by regulating the immune functions in tumor subjects.

关 键 词：锗132 NK细胞 红细胞免疫 肿瘤 人参 灵芝 

分 类 号：R977.9[医药卫生—药品] R285.5[医药卫生—药学]