甲状腺术前预防性应用抗生素的临床研究  

Clinical Research of the Glandula Thyreoidea Preoperative Prophylactic Application of Antibiotic

作　　者：蔡德[1] 许建衡[2] 方玉珊[2] 蔡小燕[1] 杨绮华[1] 

机构地区：[1]汕头大学医学院第一附属医院药剂科,广东汕头515041 [2]汕头大学医学院第一附属医院普外科,广东汕头515041

出　　处：《今日药学》2008年第4期35-37,共3页Pharmacy Today

基　　金：2007年广东省医院药学研究基金项目(编号:200727)

摘　　要：目的研究甲状腺手术术前预防性应用抗生素是否有利于避免术后呼吸道感染等易感疾病的发生。方法符合纳入标准的患者随机分为两组,A组术前不使用抗生素;B组术前1/2h予以静脉推注头孢拉定2.0g。观察患者术前1天及术后第1、3天的体温、白细胞计数及分型、C-反应蛋白、喉咽拭子痰培养、胸部平片及患者有无畏寒、发热、咳嗽、咳痰、胸闷、气促等呼吸道感染症状。结果本研究2组间比较,术前,术后第1天,第3天C-反应蛋白,血白细胞和最高体温组间比较,差别无显著性意义(P>0.05)。结论术前使用抗生素与术前不使用抗生素对于术后呼吸道感染等易感疾病的发生无显著性差别,提示术前预防性应用抗生素并不能有效避免甲状腺术后呼吸道感染的发生率。Objective To study whether the glandula thyreoidea preoperative prophylactic application of antibiotic in order to avoid the postoperative nosogenesis such as respiratory infection. Methods The patients were randomly divided into two groups. Patients in group A were treated without the glandula thyreoidea preoperative prophylactic application of antibiotic; while patients in group B were treated with vein injection of 2.0 g cefradine 1/2 h before the operation. The temperature of patients at 1 d before and 3 d after the operation was observed, result of swabs culture of laryngopharynx sputum, thoracic film, the number and typing of leukocyte, C-reactive protein, and the respiriatory infection symptom of patients, such as chilly, fever, cough, cough up phlegm, chest distress, tachypnea were all observed. Results The C-reactive protein, leukocyte, and the highest temperature of patients in those 2 groups before the operation, and 1 d and 3 d after the operation had no significant difference （P〉0.05）. Conclusion The glandula thyreoidea preoperative prophylactic antibiotic application cannot avoid the respiratory infection symptom after the operation.

关 键 词：甲状腺手术 预防性应用 抗生素 

分 类 号：R978.1[医药卫生—药品]