糖化血红蛋白水平与脉搏波速度相关性分析  

Analysis of correlation between HbA1 C and pulse ware velocity

作　　者：米树华[1] 王南晔[1] 杨红霞[1] 陶红[1] 

机构地区：[1]首都医科大学附属北京安贞医院特需医疗科,北京100029

出　　处：《中国医药》2008年第8期470-472,共3页China Medicine

摘　　要：目的探讨糖化血红蛋白（HbA1C）水平与脉搏波速度的相关性。方法将127例2型糖尿病的住院患者按照糖化血红蛋白水平分为糖化血红蛋白升高组（HbA1C〉6．5％）与对照组（HbA1C≤6．5％），测量患者的脉搏波速度及血压，检测甘油三酯、总胆固醇、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇等血脂水平。结果糖化血红蛋白升高组脉搏波速度明显高于对照组（P〈0．01）。在脉搏波速度相关因素分析中，糖化血红蛋白及收缩压与脉搏波速度显著相关（P〈0．01）。结论糖化血红蛋白与脉搏波速度具有相关性，血糖控制欠佳的糖尿病患者，动脉硬化程度加重；控制血糖及血压对于糖尿病患者大血管并发症的防治具有重要意义。Objective To evaluate the correlation between HbA1C and pulse ware velocity （PWV）. Methods 127 patients with diabetes mellitus was enrolled into two groups based on HbA1C level： 1. Group with increased HbA1C （ HbA1C 〉 6.5% ） and the control group （ HbA1C ≤6.5% ）. We measured the PWV and blood pressure, nitroglycerin, total cholesterol and blood plasma lipids of all the patients. Results The PWV of the patients with HbA~ C 〉 6.5 % were significantly higher than of that in control group （ P 〈 0.01 ）. The HbA1C level and systolic pressure was correlated to PWV （ P 〈 0.01 ）. Conclusion There was strong correlation between HbA1C and PWV. The arteriosclerosis will become more severe if the blood glucose is not controlled well. Controlling the blood glucose and blood pressure to a proper level is exceedingly important in prevention of complications of large blood vessels in patients with diabetes mellitus.

关 键 词：动脉硬化 糖化血红蛋白 脉搏波速度 

分 类 号：R543.5[医药卫生—心血管疾病]