克霉唑联合苦参凝胶治疗重度外阴及阴道假丝酵母菌病  

Treatment of severe vulvovaginal candidiasis with clotrimazde combined with gelatin kushen

作　　者：陈炳锦[1] 葛亚娟[1] 朱芳[1] 朱丽均[1] 陈亚萍[1] 

机构地区：[1]复旦大学附属上海市第五人民医院妇产科,上海200240

出　　处：《中国医药》2008年第8期500-501,共2页China Medicine

摘　　要：目的探讨克霉唑联合苦参凝胶治疗重度外阴、阴道假丝酵母菌病的临床治疗效果和药物不良反应。方法98例外阴、阴道假丝酵母菌病患者采用随机单盲方法，分为克霉唑组34例、苦参凝胶组33例、克霉唑加苦参凝胶组31例，治疗后7d和月经后5d评估治疗效果。结果克霉唑组临床治愈率和真菌清除率稍高于苦参凝胶组，但无统计学意义（P〉0．05），克霉唑加苦参凝胶组在治疗后第7天和月经后第5天均明显优于其他2组（P〈0．05）。3组治疗耐受性好且均无严重药物不良反应发生。结论克霉唑与苦参凝胶联合应用显著提高治疗效果，在治疗过程中未见严重局部和全身的药物不良反应，值得临床推广。Objective To evaluate the therapeutic effect and safety of gelatin Kushen in the treatment of severe vulvovaginal candidiasis. Methods Ninty-eight patients of severe vulvovaginal candidiasis were treated randomly with clotrimazole, gelatin Kushen or clotrimazole combined with gelatin Kushen. The therapeutic effect and adverse reaction were observed at 7 days after treatment and 5 days after menstruation. Results The effective rates were similar between clotrimazole and gelatin Kushen （P 〉 0. 05 ）. Compared with single drug , the effective rate of clotrimazole combined with gelatin Kushen was significantly increased （P 〈0. 05） . No adverse reaction was found. Conclusion Clotrimazole combined with gelatin Kushen was effective and safe in the treatment of severe vulvovaginal candidiasis.

关 键 词：外阴 阴道假丝酵母菌病 苦参凝胶 克霉唑 

分 类 号：R711.31[医药卫生—妇产科学] R684.3[医药卫生—临床医学]