6%羟已基淀粉130/0.4临床应用的研究进展  

Clinical Application Progress of 6%HES130/0.4

作　　者：潘四新[1] 薛玉良[2] 马维根[1] 

机构地区：[1]天津儿童医院麻醉,天津300074 [2]泰达国际心血管医院麻醉科,天津300457

出　　处：《医学综述》2008年第14期2182-2185,共4页Medical Recapitulate

摘　　要：6%羟已基淀粉130/0.4(6%HES130/0.4)是目前应用于临床的新型中分子羟已基淀粉,因相对分子质量范围窄,取代级低(0.4),具有代谢率高,扩容效果好,在组织中蓄积量小的特点。且具有:①对血流动力学改善作用优于容量治疗的"金标准"白蛋白。②具有抗炎作用,其机制来自于它能够抑制白细胞激活,及通过抑制核因子κB来降低炎性反应,还具有减少内皮细胞的损伤,抑制黏附因子释放等途径达到抗炎作用。③对凝血功能的影响仍存在争议,但合理应用,可以避免不良影响。④对肾功能有改善作用,但也有不同观点。⑤毛细血管的封闭效应。6% HES 130/0.4 is the newest HES with middle molecule used in clinic, his molecular weight distribut is the narrowest of all HES producte. Because its relative molecular mass is narrow with low grade about 0.4, it also has some features of high metabolism, good effect of fluid expansion and little accumulation in tissues. Its effects lies in several aspects, for example, ①6% HES130/0.4 has better effect in promoting hemodynamics than that of gold standard-albumin used in treating low capacity. ②6% HES130/0.4 also has effect of anti-inflammation, its mechanism maybe result from several pathways, such as inhibiting the activation of white blood cells, lowering the inflammation by inhibiting nuclear factor-κB, decreasing the endothelial injury,inhibiting the releasing of adhesion molecules ans so on. ③There are still contraversory about its effects on coagulation, but rational application in clinic can avoid its side effect on coagulation. ④6% HES130/0.4 can improve renal function although there are still some disagreements. ⑤6% HES130/0.4 has blocking effect on blood capillary.

关 键 词：6%羟已基淀粉130/0.4 血流动力学 炎性反应 凝血 肾 

分 类 号：R614[医药卫生—麻醉学]