老年小鼠肝脏组织胶原与SOD、LPO之间的关系  

Relationship between the collagen content and the superoxide dismutase activity and the lipid peroxidation content of liver in aged rats

作　　者：欧琴[1] 白大芳[1] 张鹏霞[1] 王玉民[1] 纪彪[2] 

机构地区：[1]佳木斯医学院生化教研室 [2]佳木斯市中心医院检验科

出　　处：《佳木斯医学院学报》1997年第6期3-4,共2页

摘　　要：衰老是一个复杂的生理过程,为了探讨肝脏组织胶原与 SOD、LPO 之间的关系,说明老化过程中胶原随龄变化的机理,本实验采用健康昆明小鼠,观察肝脏组织胶原及 SOD、LPO 的随龄变化。结果表明老年小鼠肝脏组织胶原明显降低,且与 SOD 呈正相关(P<0.05),与 LPO 呈负相关(P<0.01),提示胶原的变化与 SOD、LPO 有着极其密切的联系。In an attempt to surdy the mechanism of collagen decrease with aging in animal organizalions.we observed the changes in the content collagen and lipid peroxidation(LPO)and the activity superoxide dismutase(SOD)of liver.The results showed that the content of collage has relation to the SOD activity and LPO levels in liver. suggesting the dependence of collagen content upon the activity of SOD and level of LPO.

关 键 词：胶原 超氧化物歧化酶 过氧化脂质 肝 衰老 

分 类 号：R338.38[医药卫生—人体生理学]