HCV—RNA水平对HIV/HCV合并感染者HIV疾病进展影响研究  被引量:7

Impact of HCV-RNA levels on HIV-1 disease progression in Chinese HIV/HCV co-infected individuals

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作  者:刘静[1] 姜拥军[1] 张旻[1] 陈昕[1] 张子宁[1] 周立平[1] 范霞[1] 王亚男[1] 胡清海[1] 代娣[1] 丁海波[1] 尚红[1] 

机构地区:[1]中国医科大学附属第一医院卫生部艾滋病免疫学重点实验室,沈阳110001

出  处:《中华微生物学和免疫学杂志》2008年第6期503-507,共5页Chinese Journal of Microbiology and Immunology

基  金:卫生部艾滋病防治应用性研究项目(WA2006-02);国家“十五”科技攻关课题(2004BA719A12);辽宁省科技攻关项目(2005225001)

摘  要:目的探讨人免疫缺陷病毒(HIV)和丙型肝炎病毒(HCV)混合感染者HCV—RNA水平对HIV感染疾病进展的影响。方法采用横断面研究对391例不同途径HIV感染者进行抗HCV—IgG、HCV—RNA、HIV—RNA、T淋巴细胞计数及其他免疫活化指标检测,比较HCV—RNA水平高组和低组病毒学及免疫学相关指标差别,分析HCV—RNA与HIV—RNA、CD4^+T淋巴细胞计数的相关性。结果(1)有偿供血组(93%)和静脉吸毒组(97.5%)抗HCV-IgG阳性率显著高于性接触组(20.1%);在抗HCV—IgG阳性的HIV感染者中,静脉吸毒组HCV—RNA阳性率(89.9%)显著高于有偿供血组(48.3%)及性接触组(62.5%),P均〈0.01。(2)HCV—RNA水平和HIV—RNA水平正相关(r=0.237,P〈0.01),与CD4计数负相关(r=-0.201,P〈0.05)。(3)HCV—RNA高组免疫活化标志物HLA—DR表达高于HCV—RNA低组(P〈0.01)。结论高水平的HCV—RNA可能是HIV感染疾病进展的危险因素之一。Objective To investigate the impact of hepatitis C virus (HCV)-RNA levels on human immunodeficiency virus (HIV)-1 disease progression in Chinese HIV/HCV co-infected individuals. Methods Cross-sectional analysis was performed among 391 HIV-infected patients for assessment of HCVIgG, HCV-RNA, HIV-RNA, CD4 cell counts and cell surface markers of immune activation, to compare the difference of viral and immune indexes between HCV-RNA high group and HCV-RNA low group, and to elucidate the association between HCV-RNA, HIV-RNA and CD4 cell counts in HIV/HCV co-infected patients. Results (1) The percentage of anti HCV-IgG positive of former plasma donor group (93%) and drug-injection group (97.5%) were significantly higher than that of sexual transmission group (20. 1% ). The percentage of HCV-RNA positive of drug-injection group (89.9%) was significantly higher than that of former plasma donor group (48.3%) and sexual transmission group (62.5%), P 〈 0.01, respectively. (2) HCV-RNA levels were positively correlated to HIV-RNA levels ( r = 0. 237, P 〈 0.01 ) , whereas were negatively correlated to CIM cell counts (r = -0.201, P 〈 0.05 ). (3)The HLA-DR expression on T lymphocytes of HCV-RNA low group was lower than that of HCV-RNA high group (P 〈 0.01 ). Conclusion High level HCV-RNA may act as a risk factor of HIV-1 disease progression.

关 键 词:人免疫缺陷病毒 丙型肝炎病毒 合并感染 疾病进展 

分 类 号:R512.91[医药卫生—内科学] R512.6[医药卫生—临床医学]

 

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