脉冲Ho∶YAG激光与生物组织相互作用效果与残留热效应的分析  

Ho∶YAG Laser Interaction with Bio-Tissue and Its Remained Thermal Effect

作　　者：邱阳[1] 李胜文 张翼[1] 李汉明[1] 朱鹏飞[1] 董全力[1] 阮英茆 李英骏[1] 毛灵涛[3] 王超[3] 张杰[1] 

机构地区：[1]中国科学院物理研究所光物理实验室,北京100080 [2]清华大学第一附属医院,北京100083 [3]中国矿业大学,北京100083

出　　处：《中国激光》2008年第7期1105-1110,共6页Chinese Journal of Lasers

基　　金：国家973计划(2007CB815102);国家自然科学基金(60621063);清华-裕元医学科学研究基金;首都医学发展科研基金(2005-3029)资助项目

摘　　要：医疗激光在生物组织切割领域应用愈加广泛，但其作用效果与不良反应仍未形成统一的参数标准，对操作经验依赖严重，不便于推广；而激光参数的选择又对产品开发具有决定性意义。为寻求医疗激光标准化的工程优选参数，通过动物体外实验，在模拟手术环境下考察了不同能最密度Ho：YAG激光（50～400J／cm^2）与狗肾实质等组织的相互作用。获得了作用效果的统计结果、标本切片的显微图像、残留热效应记录。分析了作用效果的影响因素以及热效应的演化。研究发现，作用效果的归一化曲线在290J／cm^2存在峰值，可作为标准化工程优选参数的推荐值；影响因素和残留热效应的分析为医疗设备的改进提供了参考。Medical laser has been applied more and more broadly in bio-tissue cutting, but the efficacy and the side effect have never been standardized at parameters level, depending highly on the experiences of the operator, which causes disadvantage for the spread of this technology; while the choice of the technical parameters of the laser form a crucial factor in the developing of the product. To seek for the optimized parameters, we studied the interaction between the tissue such as the parenchyma of the dog＇s kidney and Ho：YAG laser at different energy densities （50 ～400 J/cm^2 ）, in a circumstance of operation simulated via some extra corporeal animal experiments. We got the statistical results of the interaction, the optical micrograph of the slice and the record of the remained thermal effects. We analyzed the influencing factors of the interaction and the evolution of the remained thermal effects. A peak-value exists at about 290 J/cm^2 on the unified curve of the efficacy, which can be used as the recommended value in standardizing. The analysis of the influencing factors and the remained thermal effects brings reference to the improving on the medical laser devices.

关 键 词：医用光学与生物技术 标准化 休外实验 HO:YAG激光 相互作用 固体激光 

分 类 号：R318.51[医药卫生—生物医学工程]