微小RNA在动物上的功能研究进展  

Advances in Research on MicroRNA Function in Animal

作　　者：苏小茜[1] 江培勇[2] 张峰[1] 曾养志[1] 

机构地区：[1]云南农业大学动物科学技术学院,云南昆明650201 [2]华中农业大学,湖北武汉430070

出　　处：《云南农业大学学报（自然科学版）》2008年第4期545-551,共7页Journal of Yunnan Agricultural University:Natural Science

基　　金：国家自然科学基金重点资助项目(39830190)

摘　　要：微小RNA(miRNA)是一种长约22 nt的非编码RNA,通过与mRNA碱基互补配对来靶基因进行转录后调控。在众多多细胞生物中已经鉴别出数百种miRNAs,而且大多数在进化上高度保守。虽然绝大多数miRNAs的生物学功能还不清楚,但是预测结果显示miRNAs对人类30%的基因具有表达调控作用。随着研究的深入,不断知道miRNAs的功能及其作用机制。本文就microRNAs在动物上的作用机制及其功能的研究进展作一综述。MicroRNAs （miRNAs） are small non-coding RNA molecules that post-transcriptionally regulate gene expression by base-pairing to mRNAs. Hundreds of miRNAs have been identified in various multicellular organisms and many miRNAs are evolutionarily conserved. Although the biological functions of most miRNAs are unknown, miRNAs are predicted to regulate up to 30% of the genes of the human genome. The functions and active mechanism of miRNAs were gradually revealed with the more and more further studies. In this paper, the recent advances in miRNA biological functions and active mechanism in animals were reviewed.

关 键 词：微小RNA 调控 功能 

分 类 号：Q752[生物学—分子生物学]