代谢综合征高危人群心血管危险因素综合干预效果  

Comprehensive Intervention of Cardiovascular Risk Factors in Metabolic Syndrome High-Risk Groups

作　　者：高阳[1] 毛宇强[2] 陈松[3] 张斌[2] 刘立昱[2] 魏敏[1] 胡怡[1] 熊盈[1] 陈思娇[1] 李廷富[1] 徐锦春[1] 

机构地区：[1]中国医科大学附属第一医院老年医学研究室,辽宁省沈阳市110001 [2]中国医科大学七年制医学系 [3]中国医科大学七年制89期盛京医院学生科

出　　处：《中国全科医学》2008年第14期1234-1236,共3页Chinese General Practice

基　　金：辽宁省科技攻关项目(2007225004 -3);沈阳市科学技术计划项目(1071162 -9 -00)

摘　　要：目的评价综合干预对代谢综合征(MS)高危人群心血管危险因素的影响。方法对经常住院的100例MS高危人群(干预组)进行综合干预,随访2年。另选一般临床资料与干预组相匹配的60例由于工作繁忙无时间进行系统干预的MS高危人群作为对照组。观察两组患者干预前后的腰围、体质指数(BMI)、收缩压(SBP)和舒张压(DBP)、高密度脂蛋白胆固醇(HDL-C)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)、空腹血糖(FBG)、空腹胰岛素(FINS)、胰岛素抵抗指数(HOMA-IR)和C-反应蛋白(CRP)的变化。结果干预前两组患者腰围、BMI、SBP、DBP、HDL-C、LDL-C、TG、FBG、FINS、HOMA-IR、CRP水平间差别无统计学意义(P>0.05)。干预后两组患者除LDL-C和TG外,其他各项检测指标间差别均有统计学意义(P<0.05)。结论综合干预可改善MS高危人群的肥胖,降低血压和血糖,增加HDL-C水平,降低胰岛素抵抗和CRP水平。Objective To evaluate the effects of comprehensive intervention of cardiovascular risk factors in metabolic syndrome （MS） high - risk groups. Methods Comprehensive intervention was carried out on 100 cases of repeatedly hospitalized MS high - risk population （ intervention group）, and follow - up was done for 2 years. Another 60 cases whose general data were commensurate with intervention group, who didn＇t receive intervention due to their busy work, were chosen from MS high - risk popuplation as control group. We observed the changes of waist circumference, body mass index （ BMI）, systolic blood pressure （SBP）and diastolic blood pressure （DBP）, high-density lipoprotein cholesterol （HDL-C）, triglycerides （TG）, low- density lipoprotein cholesterol （LDL- C）, fasting plasma glucose （FPG）, fasting insulin （FINS）, insulin resistance index （HOMA- IR） and C - reactive protein （CAP） before and following intervention. Results There was no significant difference in waist circumference, BMI and levels of SBP, DBP, HDL-C, LDL- C, TG, FBG, FINS, HOMA- IR, CRP between two groups before intervention （ P 〈 0. 05 ） ; significant difference was found in waist circumference, BMI and levels of SBP, DBP, HDL- C, FBG, FINS, HOMA- IR, CAP between two groups after intervention （P 〈0.05）. Conclusion Comprehensive intervention can improve obesity, increase level of HDL - C and reduce blood pressure, blood sugar and levels of insulin resistance and CRP in MS high - risk population.

关 键 词：代谢综合征 危险因素 干预性研究 

分 类 号：R541.6[医药卫生—心血管疾病]