凉润通络方及其拆方对糖尿病大鼠胃肠激素水平的影响  

Effect of Liangruntongluo Recipe and Its Decomposed Recipe MOT,CCK and SS in Gastro intesine of Rats with Diabetes

作　　者：李佃贵[1] 戎士玲[1] 王凤丽[1] 张永健[1] 

机构地区：[1]河北医科大学中医院,河北石家庄050011

出　　处：《中国药业》2008年第14期21-23,共3页China Pharmaceuticals

基　　金：国家中医药管理局中医药科学技术研究专项;项目编号:04-05JP09

摘　　要：目的探讨凉润通络方及其拆方对糖尿病大鼠胃肠运动功能改善的机制。方法雄性Wistar大鼠,采用链脲佐菌素(STZ)注射制作糖尿病大鼠模型,造模成功后不予降糖药物控制血糖。正常饲养18周后,大鼠分别予温开水、凉润通络中药、单纯通络中药、单纯滋润中药、单纯清凉中药及西沙必利灌胃,灌胃6周后检测血浆中的胃动素(MOT)、胆囊收缩素(CCK)、生长抑素(SS)。结果24周时糖尿病大鼠存在胃肠激素水平紊乱,凉润通络方可影响血液中胃肠激素的分泌和释放,作用靶点较宽,作用优于其拆方和西沙必利。结论凉润通络方在改善糖尿病大鼠胃肠功能障碍方面具有优势。Objective To study the mechanism of Liangruntongluo Recipe and its decomposed recipe in improving gastrointestinal function of diabetes mellitus （DM） rats, Methods Male Wistar rats were given streptozotocin（STZ） injection for producing diabetes mellitus（DM） rat model, After the model establishment, no hypoglycemic drugs were used to control blood sugar, After keeping the normal feeding for 18 weeks, the rats were given gastric gavage with water, Liangruntongluo Chinese medicine, pure Tongluo Chinese medicine, pure Zirun Chinese medicine, pure Qingliang Chinese medicine and cisapriede. Plasma motilin （MOT）, cholecystokinin （CCK）, somatostatin （SS） were detectedafter 6 weeks of gavage, Results In 24 week, the rats with DM presented the disorder of gastrointestinal hormone, Liangruntongluo Recipe affected the secretion and releasing of hormone in blood. The target range was wider and The effect was superior to its decomposed recipe and cisapride, Conclusion The Chinese medicine Liangruntongluo Recipe has the superiority in improving the disturbance of the gastrointestinal function of diabetes mellitus.

关 键 词：凉润通络方 糖尿病胃肠功能障碍 胃动素 胆囊收缩素 生长抑素 

分 类 号：R285.5[医药卫生—中药学] R282.71[医药卫生—中医学]