灯盏花素注射液对脑梗死病人血纤溶酶原激活剂抑制剂-1的影响  

Effect of Dengzhanhuasu Injection on Acute Cerebral Infraction and Its Influence on PAI-1

作　　者：张连彦[1] 刘志远[1] 李朝鹏 付国芬[1] 胡美芹[1] 

机构地区：[1]河北省复员军人医院 [2]邢台高等医学专科学校

出　　处：《中西医结合心脑血管病杂志》2008年第7期786-787,共2页Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease

摘　　要：目的观察灯盏花素注射液治疗急性脑梗死的临床疗效并探讨其治疗急性脑梗死的作用机制。方法将70例急性脑梗死病人随机分为治疗组和对照组,治疗组静脉输注灯盏花素注射液,两组同时给予丹参、胞磷胆碱静脉输注,共15d。观察两组临床疗效及血浆组织型纤溶酶原激活物(t-PA)和纤溶酶原激活剂抑制剂-1(PAI-1)的变化。结果治疗组显效率(57.1%)及总有效率(94.3%)明显高于对照组(31.4%、77.1%,P<0.05);治疗组治疗前PAI-1为(64.5±9.12)ng/mL,治疗后为(42.57±6.32)ng/mL,治疗前后比较有统计学意义(P<0.05),对照组治疗前为(65.08±10.59)ng/mL,治疗后为(63.34±9.30)ng/mL,治疗前后比较无统计学意义(P>0.05)。结论灯盏花素注射液通过改善纤溶活性治疗急性脑梗死安全有效。Objective To study the effect of Dengzhanhuasu injection on acute cerebral infraction and its mechanism. Methods Seventy patients （pts） with acute cerebral infarction were divided at random into two groups： Treatment group （n= 35） treated by Dengzhanhuasu injection and control group （n= 35）. All pts were treated with Danshen injection and citicoline for 15 days. Level of t - PA and PAI- 1 were detected. Results The effective rate （57.1 %） and the total efficacy rate （94.3 %） in treatment group were significantly higher than that （31.4 % and 77.1%） in control group. Compared with pre - treatment, PAI- 1 in the treatment group was significant differences. PAl - 1 in control group was no significant differences pre - and post - treatment. Conclusion Dengzhanhuasu injection could improve fibrinolytic activity in pts with acute cerebral infarction and it was safe and effective.

关 键 词：脑梗死 急性 灯盏花素注射液 纤溶酶原激活剂抑制剂-1 

分 类 号：R277.7[医药卫生—中医学]