依那普利和倍他乐克联用治疗心力衰竭  

Enalapril and metoprolol in treatment of heart failure

作　　者：杨勤[1] 张志清[1] 康林[1] 周利华[1] 赵强[1] 谢江柳 

机构地区：[1]雅安市人民医院,四川雅安625000

出　　处：《西部医学》2008年第4期727-728,共2页Medical Journal of West China

摘　　要：目的观察血管紧张素转换酶抑制剂（ACEI）依那普利与选择性β-受体阻滞剂倍他乐克联用治疗心力衰竭的临床疗效。方法将60例心衰患者采用随机双盲对照法分为观察组30例,对照组30例,均为病因和基础治疗加利尿剂。观察组加用依那普利5-10mg,每日2次,倍他乐克12.5-25mg,每日2次,对照组加用消心痛5-10mg,每日3次,地高辛0.125-0.25mg,每日1次,两组共用药8周。治疗前后采用NYHA分级,彩色多普勒超声心动图测量左心室舒张末期内径（LVEDD）、左心室收缩末期内径（LVESD）、射血分数（EF）、A/E比值等,对比治疗前后心功能改善情况。结果两组治疗均有效,但观察组治疗前后各项指标的改善较对照组显著,且舒张末期内径及射血分数比较也有显著差异。结论依那普利和倍他乐克联用较消心痛和地高辛联用治疗心功能不全疗效更好。Objective To observe clinical effect of angiotensin converting enzyme inhibitors （ACEI）-enalapril and selective β-blocker-metoprolol in treatment of heart failure. Methods 60 patients were randomly divided into two groups, including control group （30 cases） and treatment group （30 cased）. Besides routine treatments, control group gave isosorbide dinitrate and digoxin, whereas treatment group gave enalapril and metoprolol. Before and after treatment by NYHA classification, left ventricular end diastolic diameter （LVEDD）, left ventricular end systolic diameter （LVESD）, ejection fraction （EF） and A/E ratio were detected with color Doppler echocardiography to evaluated the heart function. Results Treatment group was improved more obviously in diastolic diameter and ejection fraction than that in control group. Conclusion Enalapril and metoprolol is a useful drug for cardiac insufficiency.

关 键 词：依那普利 倍他乐克 心力衰竭 

分 类 号：R541.61[医药卫生—心血管疾病]