血清1,5-脱水葡糖苷浓度变化与糖尿病酮症酸中毒监测的研究  

Study on the significance of 1,5-anhydro-D-glucitol test in diabetic ketoacidosis

作　　者：张颖[1] 于永光[2] 

机构地区：[1]哈尔滨医科大学第一临床医学院体检中心,150001 [2]哈尔滨医科大学第一临床医学院实验诊断学教研室,150001

出　　处：《中国急救医学》2008年第7期643-644,共2页Chinese Journal of Critical Care Medicine

基　　金：黑龙江省科学技术厅攻关课题项目(No.200220101)

摘　　要：目的检测糖尿病酮症酸中毒患者血清1,5-脱水葡糖苷(1,5-AG),评价对糖尿病酮症酸中毒患者血糖(BG)、血酮体的控制效果,对糖尿病酮症酸中毒患者的治疗及判定预后提供科学依据。方法将确诊为糖尿病酮症酸中毒患者(n=23例),使用酶法测定1,5-脱水葡萄血糖、乙酰乙酸(AcAc)、β-羟丁酸(β-HBA)1次/d,连续观察4 d;正常体检者对照组(n=58例),所得数据进行统计学分析比较。结果对照组与糖尿病酮症酸中毒组1,5-脱水葡糖苷、血糖、β-羟丁酸+乙酰乙酸差异均有统计学意义(P<0.01)。在糖尿病酮症酸中毒组内1,5-脱水葡糖苷与血糖在连续观察监测的4 d内,呈高度的负相关(r=-0.889);1,5-脱水葡糖苷与β-羟丁酸+乙酰乙酸呈高度负相关(r=-0.9207)。结论1,5-脱水葡糖苷检测可以做为较短时间内血糖、血酮体控制的灵敏指标。Objective In order to provide scientific evidences for the treatment of diabetic keto- acidosis（DKA） patients by examining the level of 1,5 - anhydro -D -glucitol（ 1,5-AG） and observing the effect of serum 1,5 -AG on the control of the patients/blood sugar and blood ketone bodies. Methods, 1,5 -AG, blood sugar, AcAc and β-HBA in 23 DKA patients were examined once a day for 4 day, by enzyme and were compared with those in 58 healthy peoples. Results There were the obvious differences in 1,5 -AG, blood sugar, AcAc and β-HBA between healthy people and DKA patients （P 〈 0. 01 ）. There were negative correlation between 1,5 - AG and blood sugar in the DKA patients within 4 days （ r = - 0. 889 ）. At the same time, there were also negative correlation between 1,5 - AG ant AcAc＋β - HBA （ r = - 0.9207 ）. Conclusions 1,5 - AG test could be a sensitive index for the control of blood sugar and blood ketone bodies during a short time.

关 键 词：1 5-脱水葡糖苷 血糖 血酮体 糖尿病酮症酸中毒 

分 类 号：R587.2[医药卫生—内分泌]