猪等孢球虫感染仔猪血液生理生化指标动态变化  

Dynamic Observation on the Blood Physiological Index and Serum Biochemical Values of Piglets Infected with Isospora suis

作　　者：宁长申[1] 王芳[2] 张龙现[2] 崔会玲[3] 朱静静[2] 姚雷[2] 菅复春[2] 李祥瑞[1] 

机构地区：[1]南京农业大学动物医学院,江苏南京210095 [2]河南农业大学牧医工程学院,河南郑州450002 [3]郑州大学第二附属医院检验科,河南郑州450014

出　　处：《河南农业大学学报》2008年第3期306-312,共7页Journal of Henan Agricultural University

基　　金：河南省基础与前沿技术研究计划项目(072300430030)

摘　　要：应用纯种猪等孢球虫（Isospora suis）孢子化卵囊人工感染9头6日龄仔猪，检测了感染前1d和感染后1，3，6，9，11d时血液生理生化指标、结果表明，仔猪感染I．suis后，白细胞数在感染后1d开始增多，11d达最高；红细胞在感染后3d开始减少，9d最低，11d时恢复到感染前水平．血清丙氨酸氨基转移酶活性逐渐升高，感染后11d时达最高值；天冬氨酸转氨酶感染后6d升高并达到最高；感染后1d碱性磷酸酶活性下降，11d最低；血清乳酸脱氢酶、γ-谷氨酰转肽酶、α-羟丁酸脱氢酶活性均呈下降趋势，但无显著差异、感染后1d时白蛋白含量下降，至11d恢复到正常水平；球蛋白含量持续下降，但差异不显著．血清葡萄糖含量升高但无显著变化．感染后1～3d时血清尿素氮含量降低，之后逐渐升高，至11d时达最高；尿酸在感染后1～3d升高，之后持续下降，至11d时最低、血清总胆固醇持续降低；甘油三酯在感染后1～9d升高，11d时恢复到感染前水平．血清K^＋含量在感染后持续降低，但差异不显著．嗜中性白细胞，单核细胞，血红蛋白含量，红细胞压积，总蛋白含量，Na^＋，Cl^-，Ga^2＋，Mg^2＋含量均无明显变化．In order to reveal the dynamic changes of the blood physiological index and serum biochemical values of piglets infected with Isospora suis, nine six-day-old piglets were inoculated with l. suis sporulated occysts. The blood physiological index and serum biochemical values were checked. The checked-time are 1 day before and 1, 3, 6, 9, 11 days post-infection （DPI）, respectively. The results show that white blood cell rose on 1 DPI and reached peak value on 11 DPI. Red blood cell reduced on 3 DPI and came to the lowest point on 9 DPI, which was refection on 11 DPI. Alanine aminotransferase activity rose gradually and reached peak value on 11 DPI. Aspartate aminotransferase became the peak value on 6 DPI. Alkaline phosphatase descented on 1 DPI, and came to the lowest point on 11 DPI. Lactate dehydrogenase, γ-glutamyhransferase and α-hydroxybutyrate dehydrogenase were reduced but had no significant change. Albumin reduced on 1 DPI, which was refection on 11 DPI. Globulin decreased, but has no significant change. Glucose rose but has no significant change. Blood urea nitrogen decreased on 1 - 3 DPI, then rose gradually up to 11 DPI. Uric acid rose on 1 - 3 DPI, then deduced until 11 DPI. Total cholesterol decreased. Triglyeride rose on 1 -9 DPI and returned to pre-infeetion level on 11 DPI. K^＋ content reduced on post infection but the difference was not obvious. However, leucocyte neutrophil, lymphomonocyte, hemoglobin, haematocrit, total protein, Na^＋, Cl^- , Ga^2＋ and Mg^2＋ didn＇t have significant change.

关 键 词：猪等孢球虫 生理生化指标 仔猪 

分 类 号：S852.72[农业科学—基础兽医学]