脂代谢紊乱对2型糖尿病患者早期胰岛素分泌的影响  

Effects of dyslipidemia on early insulin secretion in patients with type 2 diabetes mellitus

作　　者：田景伦 周毛吉[2] 何书经 李薇[1] 

机构地区：[1]成都市温江区人民医院内分泌科,611130 [2]甘肃中医学院临床医疗系

出　　处：《中国糖尿病杂志》2008年第7期391-393,共3页Chinese Journal of Diabetes

摘　　要：目的了解脂代谢紊乱对2型糖尿病(T2DM)患者早期胰岛素分泌功能的影响。方法93例未经调脂和降糖治疗的新诊T2DM患者根据血脂水平分为正常血脂组(B组)、单纯TG升高组(C组)和混合血脂升高组(D组),20例体检正常者为健康对照组(A组),根据OGTT结果计算和分析早期胰岛素分泌指数ΔI30/ΔG30和HOMA-IR。结果各组之间ΔI30/ΔG30比较:B、C、D组与A组之间差异有统计学意义(P<0.01,P<0.05和P<0.05),C、D组与B组之间差异有统计学意义(P<0.05),C组与D组之间差异无统计学意义(P>0.05);各组之间HOMA-IR比较:B、C、D组与A组之间差异有统计学意义(P<0.05),D组与B组之间差异有统计学意义(P<0.01),C组与B组之间差异无统计学意义(P>0.05)。结论T2DM患者同时存在早期胰岛素分泌缺陷和胰岛素抵抗(IR),血脂异常与早期胰岛素分泌功能降低和IR相关。Objective To investigate the effects of dyslipidemia on early insulin secretion in patients with type 2 diabetes mellitus（T2DM）. Methods 93 newly diagnosed T2DM patients without lipid-lowering and anti-hyperglycemic therapies were divided into 3 groups： normal lipids （group B） ,single high triglyceride （group C）, and high triglyceride and high total cholesterol with or without low HDL-cholesterol or high LDL-cholesterol （group D）. The 20 non-diabetic subjects with normal lipids were healthy control group（group A）. Early insulin secretion indexes （△I30/△G30 ） and insulin resistance indexes （HOMA-IR） were calculated from oral glucose tolerance test. Results Compared with group A,group B,C and D had a significantly lower △I30/△G30 （P〈0.01 ,〈0. 05 and〈0.05） and a higher HOMA-IR（all P〈0.05）. In contrast to group B,the group C and D had a significantly lower △I30/△G30 （both P〈0. 05） ,and the group D had a significantly higher HOMA-IR（P〈0.01） in T2DM groups. But no significant differences in the △I30/△G30 between group C and D,and in HOMA-IR between group B and C（both P〉0. 05）,were observed. Conclusions High triglyceride reduces early insulin secretion function and cholesterol abnormalities increase insulin resistance in T2DM.

关 键 词：糖尿病 2型 血脂异常 早期胰岛素分泌 

分 类 号：R587.1[医药卫生—内分泌]