肥胖及糖调节受损患者血视黄醇结合蛋白4的变化及临床意义  

Change of serum retinol binding protein-4 level and its clinical significance in patients with obesity and impaired glucose regulation

作　　者：潘优津[1] 赵向彤[1] 吴朝明[1] 汪大望[2] 

机构地区：[1]温州医学院附属二院内分泌科,浙江325000 [2]温州医学院附属一院内分泌科

出　　处：《中国糖尿病杂志》2008年第7期400-401,404,共3页Chinese Journal of Diabetes

基　　金：温州市科技局课题基金资助项目(计划编号Y20060150)

摘　　要：目的研究超重、肥胖(OW、Ob)及糖调节受损(IGR)患者血视黄醇结合蛋白4(RBP-4)变化及与胰岛素抵抗(IR)的关系。方法ELISA法测正常糖耐量(NGT)组52例及IGR组58例的血RBP-4水平。结果各组RBP-4渐升高,组间差异有统计学意义;与腰围、WHR、HOMA-IR、TG、FPG正相关(r分别为0.289、0.322、0.377、0.41、0.432,P均<0.01);FPG、TG、WHR为其独立相关因素(r2分别为0.186、0.305、0.340)。结论OW/Ob及IGR者血RBP-4升高,FPG、TG、WHR为其独立相关因素。Objective To assay serum retinol binding protein-4（RBP-4） levels in subjects with overweight or obesity（OW/Ob） and impaired glucose regulation（IGR）, and to explore the correlation between RBP-4 and insulin resistance. Methods RBP-4 were determined by ELISA in 52 NGT and 58 IGR patients. Results RBP-4 was correlated with WC, WHR,HOMA-IR,TG,FBG （r=0. 289,0. 322,0. 377, 0.41,0. 432, all P〈0.01）. FBG, TG, W HR were independent influencing factors for RBP-4 （r^2= 0. 186, 0. 305,0. 340 respectively）. Conclusions RBP-4 is increased in subjects with OW/Ob or IGR and correlated with FPG,TG and WHR.

关 键 词：视黄醇结合蛋白4 糖调节受损 胰岛素抵抗 

分 类 号：R589.2[医药卫生—内分泌] R587.1[医药卫生—内科学]