胰岛素水平与轻度认知障碍关系的临床研究  

A clinical study of the relationship between insulin level and mild cognitive impairment in type 2 diabetes subjects

作　　者：司俊霞[1] 谈跃[2] 徐勉[2] 杜娟[2] 赵晓红[2] 牛学琴[2] 潘毅[2] 

机构地区：[1]天津市武警医学院附属医院脑系科,300162 [2]昆明医学院第二附属医院老年病科

出　　处：《中国糖尿病杂志》2008年第7期418-420,共3页Chinese Journal of Diabetes

摘　　要：目的研究2型糖尿病(T2DM)患者血浆胰岛素水平与轻度认知障碍(MCI)的关系及分析MCI的相关危险因素。方法T2DM患者101例分为MCI组与NC组。均进行MMSE、GDS、CMS、ADL等评测,并检测Ins、HbA1c、血常规、血脂、肝肾功、血压、心电图、头颅CT等,进行成组t检验、直线相关及Logistic回归分析。结果(1)糖尿病MCI患者FIns、2hIns、3hIns水平明显升高(P<0.05)。(2)Logistic回归分析最终进入方程的是受教育程度、2hIns水平、高血压、HbA1c。结论高胰岛素血症在糖尿病MCI的发生发展中起重要作用,提高胰岛素的敏感性有利于改善糖尿病患者的认知功能。Objective To investigate the relationship between insulin level and mild cognitive impairment（MCI） of type 2 diabetes and analyze the risk factors for MCI. Methods We collected 101 type 2 diabetes subjects who were divided into two groups：MCI and normal cognition（NC）. All subjects were evaluated with cognition scores of MMSE, GDS, CMS, ADL. Insulin, glycosylated hemoglobin, blood routine test,blood pressure, ECG, brain CT were detected. Independent t-test, correlation and multiple regression analysis were performed. Results 1. The diabetic patients with MCI showed the higher levels of insulin at fasting, 2hr and 3hr after meal than did NC（P〈0. 05）. 2. Education, insulin level at 2hr after meal, hypertension,and high glucose were variables entering into the equation. Conclusions Hyperinsulinemia contributes to the pathogenesis and development of diabetic MCI.

关 键 词：胰岛素水平 认知功能障碍 轻度 危险因素 糖尿病 

分 类 号：R587.1[医药卫生—内分泌] R749.1[医药卫生—内科学]