2型糖尿病患者胰岛素抵抗和β细胞功能与代谢综合征的相关性  

The association of insulin resistance and β-cell function with metabolic syndrome in T2DM

作　　者：方堃[1] 吕肖锋[1] 纪欣[1] 

机构地区：[1]北京军区总医院内分泌科,100700

出　　处：《中国糖尿病杂志》2008年第6期347-348,共2页Chinese Journal of Diabetes

摘　　要：目的测定2型糖尿病(T2DM)合并代谢综合征(MS)患者60例、单纯T2DM患者56例和正常对照(NC)组60例的空腹血糖(FPG)、空腹胰岛素(FIns)、血压(BP)、血脂、腰围(WC),计算HO-MA-IR和HOMA-β。结果MS组胰岛素抵抗水平明显高于T2DM组及NC组;胰岛β细胞功能明显低于T2DM组和NC组,差异均有统计学意义(P<0.05)。MS组HOMA-IR与FPG、WC呈正相关(P<0.05)。结论合并MS的T2DM患者的HOMA-IR最高,HOMA-β最低。T2DM患者HO-MA-IR和HOMA-β与MS密切相关。Objective To research the association of IR and β-cell function with MS in T2DM.Methods 116 T2DM subjects were divided into two groups：MS（n=60）and T2DM（n=56）,and FIns,FPG,BP and other items were measured.Results HOMA-IR was significantly higher in MS than in T2DM and control group（P〈0.05）.HOMA-β was significantly lower in MS than in T2DM and control group（P〈0.05）.And FPG,waist circumference（WC）in MS group were positively correlated with the IR level（P〈0.05）.Conclusions The HOMA-IR was highest in T2DM with MS,and HOMA-β was lowest in T2DM with MS.

关 键 词：2型糖尿病 胰岛素抵抗 胰岛Β细胞功能 代谢综合征 

分 类 号：R587.1[医药卫生—内分泌] R589[医药卫生—内科学]