2型糖尿病与β细胞素基因外显子1 Cys7Gly多态性的相关性研究  

The betacellulin gene exon 1 Cys7Gly polymorphism is associated with pathogenesis of type 2 diabetes

作　　者：李金金[1] 张喆[1] 刘德敏[1] 李金娥[1] 

机构地区：[1]天津医科大学代谢病医院6楼内分泌科,300070

出　　处：《中国糖尿病杂志》2008年第6期364-366,共3页Chinese Journal of Diabetes

摘　　要：目的探讨β细胞素基因外显子1Cys7Gly多态性与2型糖尿病(T2DM)的关系。方法采用聚合酶链反应,限制性片段长度多态法检测天津地区211名T2DM患者和102名正常对照者β细胞素基因外显子1基因型,比较两组G等位基因频率差异。结果在BMI≥24kg/m2受试者,对照组G等位基因频率为7.3%,T2DM组为0.4%,两组差异有统计学意义(P<0.05)。结论β细胞素基因外显子1Cys7Gly多态性可能与部分国人T2DM发生相关,TG基因型在T2DM发病中可能具有一定保护作用。Objective To study the relationship between the betacellulin gene exon 1 Cys7Gly polymorphism and pathogenesis of type 2 diabetes.Methods The 102 healthy controls and 210 patients with type 2 diabetes in Tianjin were enrolled.The exon 1 Cys7Gly genotypes of betacellulin gene were detected by PCR-RFLP method and the frequencies of the genotype and allele were analyzed and compared between two groups.Result For the subjects with BMI≥24kg/m^2,the frequency of G allele was higher in control subjects than in T2DM case（7.3% vs 0.4%,P〈0.05）.Conclusion The betacellulin gene exon 1 Cys7Gly polymorphism is possibly associated with pathogenesis of type 2 diabetes in Chinese in Tianjin.The TG genotype may play a protective role in type 2 diabetes.

关 键 词：Β细胞素 糖尿病 2型 限制性片段长度多态性 

分 类 号：R587.1[医药卫生—内分泌]