胰岛素短期强化治疗对血、尿内皮素和尿白蛋白排泄率的影响  

The effects of short-term insulin intensive treatment on serum and urine endothelin-1 and urine albumin excretion rate

作　　者：吕以培[1] 张素华[2] 黄永婵[1] 符春晖[3] 李舒敏[1] 

机构地区：[1]钦州市第二人民医院内分泌科,广西535000 [2]钦州市第二人民医院检验科,广西535000 [3]钦州市第二人民医院心内科,广西535000

出　　处：《中国糖尿病杂志》2008年第6期370-371,共2页Chinese Journal of Diabetes

基　　金：广西科学基金资助项目(桂科基金0342062)

摘　　要：对32例尿白蛋白排泄率(UAER)增高的初诊2型糖尿病患者行胰岛素短期强化治疗,血糖下降平稳2周后与治疗前比较,FBG、FA、HOMA-IR、HOMA-β、UAER、UET-1、SET-1的差异均有统计学意义,FBG、HOMA-IR分别与UAER、UET-1与SET-1呈显著的正相关。胰岛素强化治疗能改善高血糖引起的内皮功能障碍、降低UAER并改善胰岛素抵抗。32 newly diagnosed type 2 diabetic patients who were in hyperglycemia and high urine albumin excretion rate（UAER）were treated with short-term intensive insulin treatment.FBG,FA,HOMA-IR,HOMA-β,UAER,UET-1 and SET-1 showed very significant differences between pre-and post-treatments after blood sugar declined for 2 weeks.FBG and HOMA-IR were significantly and positively correlated with UAER,UET-1,SET-1.Insulin intensive treatment can alleviate UAER,insulin resistance and the hyperglycemic endothelial dysfunction.

关 键 词：胰岛素强化治疗 高血糖 胰岛素抵抗 内皮功能障碍 尿白蛋白排泄率 

分 类 号：R587.2[医药卫生—内分泌]