盐敏感性高血压大鼠模型的研究进展  

Advances in Rat Models of Salt-sensitive Hypertension

作　　者：崔慧慧[1] 杨建一[1] 李莉[1] 

机构地区：[1]山西医科大学细胞生物与遗传学教研室,太原030001

出　　处：《中国比较医学杂志》2008年第7期68-71,共4页Chinese Journal of Comparative Medicine

基　　金：山西省高校科技研究开发项目(20051302);山西医科大学基础医学院"学科研究方向建设基金"(No.20040708);山西省自然科学基金项目(200811076-1)

摘　　要：高血压是多基因遗传和多个环境因素相互作用的结果,盐的摄入在高血压的形成中起着关键的作用。本文就感觉神经损伤、Dahl种、醋酸脱氧皮质酮和部分肾切除等方法建立的盐敏感性高血压大鼠模型的特点及其病理生理学变化作一综述,为进一步研究盐敏感性高血压发病的机制提供依据。Hypertension is a complex and multifactorial disease resulting from the interaction of multiple genetic and environmental factors, salt intake plays a pivotal role in the development of hypertension. In order to provide evidence for studying the pathogenesis of salt-sensitive hypertension, the characteristic and pathophy- siological variations of salt-sensitive hypertensive rat model induced by sensory denervation, Dahl, DOCA and subtotal nephrectomy were reviewed in the paper.

关 键 词：高血压 大鼠模型 

分 类 号：R544.1[医药卫生—心血管疾病]