大肠癌中蛋白酶体亚基PSMA7的高表达与肝转移的关系  

High expression of proteasome subunit PSMA7 in colorectal cancer is significantly correlated with liver metastasis

作　　者：胡晓彤[1] 陈薇[1] 王达[1] 石青岚[1] 张敷彪[1] 廖永强[1] 金梅[2] 何超[1] 

机构地区：[1]浙江大学医学院附属邵逸夫医院生物医学研究(治疗)中心浙江省生物治疗重点实验室 , [2]浙江大学医学院附属邵逸夫医院病理科

出　　处：《中华肿瘤杂志》2008年第7期515-518,共4页Chinese Journal of Oncology

基　　金：浙江省自然科学基金资助项目（Y206090）

摘　　要：目的探讨蛋白酶体亚基PSMA7在大肠癌中的表达及意义。方法应用免疫组化法检测手术切除的62例原发大肠癌组织、34例转移淋巴结和13例肝转移组织中PSMA7的表达，并分析PSMA7的表达与临床病理之间的关系。结果PSMA7在正常大肠组织中均为阴性或弱阳性，而在38．7％（24／62）原发大肠癌组织、52．9％（18／34）转移淋巴结和100％（13／13）肝转移组织中高表达，且原发大肠癌组织的PSMA7高表达与肝转移密切相关（P=0．028）。PSMA7高表达组的患者生存率明显低于PSMA7低表达组（P=0．0008）。在生存率多因素分析中，PSMA7表达为影响患者预后的独立因素（P=0．004，相对危险度5．057，95％可信区间为1．682～15．201）。结论PSMA7可能在大肠癌的进展中起重要作用，评估原发大肠癌组织中PSMA7的表达水平对判断是否继发肝转移有一定指导意义。Objective To investigate the correlation between the proteasome subunit PSMA7 expression in colorectal cancer and its role in liver metastasis. Methods To identify the PSMA7 protein expression in 62 primary site colorectal cancers, 34 lymph node metastatic sites and 13 liver metastatic sites by immunohistochemistry and clarify the correlation of its expression with the clinicopathological parameters. Results High expression of PSMA7 was detected in 38.7% （24/62） of primary site colorectal cancer, 52.9% （18/34） of lymph node metastatic sites and 100% （13/13） liver metastatic sites but not in the normal colorectal tissue. High expression of PSMA7 was significantly correlated with liver metastasis （ P = 0. 028 ）. The survival rate was significantly lower in patients with high expression of PSMA7 than in those with low expression of PSMA7 （ P = 0. 0008 ）. As well, in multivariate analysis, PSMA7 expression demonstrated to be an independent prognostic factor （P = 0. 004, relative risk 5. 057; 95% confidence interval, 1. 682-15. 201 ）. Conclusion PSMA7 may play an important role in the colorectal cancer progression. Evaluation of PSMA7 expression in primary colorectal cancer at the time of surgery might be a valuable test in defining patients with a high risk of developing liver metastasis.

关 键 词：PSMA7 蛋白酶体 结直肠肿瘤 肿瘤转移 

分 类 号：R686[医药卫生—骨科学]