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作 者:陈苘[1,2] 胡迪生[1,2] 简乐[1,2] 曹文俊 张国军[1,2]
机构地区:[1]浙江医科大学公共卫生学院 [2]杭州市职业病防治院
出 处:《中国工业医学杂志》1997年第6期325-327,共3页Chinese Journal of Industrial Medicine
摘 要:目的:探讨二硫化碳(CS2)对作业工人肾功能的影响及其与脂质过氧化的可能联系。方法:对94名CS2作业工人和53名不接触CS2及其他毒物者进行尿蛋白、尿酶、LPO及SOD的观察,以非参数统计K-W法和等级相关法进行数据分析。结果:CS2作业工人尿AKP活性和红细胞LPO较对照组明显升高(P<0.01)。To observe the influences of carbon disulfide on kidney and the relationship between its nephrotoxicity and lipid peroxidation,94 workers exposed to CS2 and 53 controls were investigated,their urine protern and enzyme,erythrocyte LPO and SOD were determined in the study.Data were analyzed with NPAR KW test and rank correlation method.Results showed that the urine AKP and erythocyte LPO in CS2 exposed workers were significantly increased(P<0001).It was suggested that CS2 might increase free radical production in living cells which might induce slight damage in kidney.
关 键 词:二硫化碳 肾功能 尿酶 过氧化脂质 超氧化物歧化酶
分 类 号:R135.1[医药卫生—劳动卫生] R994.3[医药卫生—公共卫生与预防医学]
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