等梯度羟基磷灰石涂层结构对狗骨-植入体间隙愈合的增强作用  

Enhancement Effect of the Isogradient Hydroxyapatite-Coating on Gap Healing

作　　者：熊传芝 杨庆铭[1,2,3] 王毅[1,2,3] 曾绍先[1,2,3] 彭树进 

机构地区：[1]南京铁道医学院附属徐州医院 [2]上海市伤骨科研究所 [3]中国科学院上海硅酸盐研究所

出　　处：《南京铁道医学院学报》1997年第4期246-248,共3页Journal of Nanjing Railway Medical College

摘　　要：目的：观察等梯度羟基磷灰石－骨界面间隙内成骨反应。方法：应用经皮骨植入体模式，在１２条狗的双侧股骨上共植入９６个等梯度羟磷灰石（ＨＡ）表面涂层及非涂层钛合金栓。术中在植入体周围预置１ｍｍ间隙。分别于术后６、１２及１８周处死取材。测定界面抗剪强度并作组织学观察。结果：术后每一时间段涂层植入体界面抗剪强度均显著高于非涂层者。涂层植入体表面间隙内充满新生骨，骨与涂层结合紧密，而非涂层植入体表面与骨组织间常见纤维组织存在。结论：这种等梯度ＨＡ涂层结构具有增强骨－植入体界面间隙骨性愈合的作用。bjective:The purpose of this study was to evaluate the bone formation characteristics at the gap between bone and isogradient hydroxyapatite(HA) coatings.Method:A total of 96 plugs with or without isogradient HA-coating were implanted into the bilateral femura of 12 dogs at random,using a percutaneous implant model.A gap in 1mm wide was pre-saved around the plugs during operation.The animals were killed and the specimens were made for interfacer shear strength mesurement and histologic study.Result:Isogradient HA-coated implants had a greater average interface shear strength than the uncoated ones at each time span.The gaps aroud the HA-coated plugs were filled with newly formed bone and no fibrous tissue was found as that was usually observed around the uncoated plugs.Conclusion:The isogradient HA coating has an enhancement effect on gap healing around the implants.

关 键 词：羟基磷灰石 等梯度涂层 间隙愈合 狗 骨植入体 

分 类 号：R318.08[医药卫生—生物医学工程]