原发性高血压患者红细胞内Ca^(2+),Mg^(2+)水平及细胞膜ATP酶活性  

Erythrocyte Ca^2+ ,Mg^2+ Levels and Cell Membrane Adenosine Triphosphatase Activity in Patients with Essential Hypertension

作　　者：符云峰[1] 李红[1] 王素敏[1] 卢振敏[1] 李素琴[1] 

机构地区：[1]河北省医学科学院实验医学研究所生化研究室

出　　处：《高血压杂志》1997年第4期279-281,共3页Chinese Journal of Hypertension

基　　金：河北省自然科学基金

摘　　要：对正常人及原发性高血压患者细胞内、外Ｃａ２＋、Ｍｇ２＋浓度和细胞膜ＡＴＰ酶活性之间的关系进行评价。方法检测３２名正常人（ＮＴ），５５例原发性高血压病（ＨＴ）患者血浆和细胞内Ｃａ２＋、Ｍｇ２＋浓度（原子吸收法），细胞膜ＡＴＰ酶活性（比色法）。结果ＨＴ组血浆Ｃａ２＋浓度明显低于ＮＴ组，红细胞内Ｃａ２＋浓度明显高于ＮＴ组，红细胞膜Ｎａ＋－Ｋ＋－ＡＴＰ酶及Ｃａ２＋－ＡＴＰ酶活性明显低于ＮＴ组。血浆Ｍｇ２＋和红细胞内Ｍｇ２＋浓度与ＮＴ组无明显差别。结论原发性高血压患者细胞膜Ｎａ＋－Ｋ＋－ＡＴＰ酶和Ｃａ２＋－ＡＴＰ酶活性明显减低，血浆Ｃａ２＋水平明显减低，红细胞内Ｃａ２＋超载。反映膜缺陷和离子运输系统失常与原发性高血压发病有关。而细胞内、外Ｍｇ２＋水平变化与高血压之间的关系须进一步研究。Aim\ To assess the relationship between intracellular Ca^2+ ,Mg^2+ and cell membrane adenosine triphosphatase(ATPase)activity in normotensive and hypertensive subjects.\ Methods\ Plasma Ca^2+ ,Mg^2+ and intracellular Ca^2+ ,Mg^2+ were measured by atomic absorption spectrophotometry,and cell membrane ATPase activity was determined by a colorimetric method in 32 normotensives and 55 patients with esstial hypertension.\ Results\ The hypertensive group consistenly demonstrated depressed activity of each ATPase studied,with significantly lower plasma Ca 2+ level and higher intracellular Ca 2+ level compared with the normotensive group,respectively.\ No significant difference was found either of plasma Mg 2+ or intracellular Mg 2+ level between the two groups.\ Conclusions\ Patients with essential hypertension have widespread depression of cell membrane Na +K +ATPase and Ca 2+ ATPase activities with plasma Ca 2+ depletion and cytosolic Ca 2+ overload,which may reflect an underling membrane abnormality in essential hypertension.\ The cellular abnormalities may be related to the defective transport mechanisms that in turn may be aggravated by plasma Ca 2+ depletion.

关 键 词：钙 镁 细胞膜ATP酶 红细胞 高血压 病理 

分 类 号：R544.102[医药卫生—心血管疾病]