庚型病毒性肝炎17例的临床和病原学分析  

Clinical and Seroetioligical Analysis of Viral Hepatitis G

作　　者：贾青青 许家璋 徐俊杰 汪茂荣 

机构地区：[1]扬州市苏北人民医院传染科,扬州225001 [2]解放军第八一医院肝病研究所,扬州210002

出　　处：《临床消化病杂志》1997年第4期150-153,共4页Chinese Journal of Clinical Gastroenterology

摘　　要：目的：对南京地区庚型病毒性肝炎的临床和病原学特点进行分析。方法：用反转录聚合酶链反应法检测血清ＨＧＶ－ＲＮＡ。从２７４例病毒性肝炎患者中检测出１７例庚型病毒性肝炎，观察其临床表现及血清病原学标志，并分析庚型肝炎病毒部分核酸序列。结果与结论：１７例患者男性成年人多见，全年散发，经输血感染为重要传染途径。ＨＧＶ可以单独感染，也可重叠（混合）其它肝炎病毒感染。少数为急性肝炎，多数为慢性肝炎或肝硬化。Aims: To study the clinical features of viral hepatitis G and HGV-RNA type in Nanjing area. Methods: Seventeen patients with hepatitis G were collected from in-patients with HGV-RNA positive (RT-PCR assay). The markers of hepatitis A to G were detected in all patients and HGV-RNA sequence were analysed in the patients. Results: Eight of 17 patients had blood transusion history. There were 8 cases of patients with pure HGV infection and the other 9 cases had superinfection with HBV and/or HCV. Eight patients with pure HGV infection patients had no or slight symptoms, 2 patients showed chronic sererious hepatitis in 3 cases with HGV + HBV superinfection and 7 patiens showed chronic hepatitis or cirrhosis. The HGV-RNA sequence analysis showed that the HGV Nanjing strain had 82. 27% -93.94% sequence homology with HGV American strains and Hebei strain. Conclusions: Hepatitis G may result from blood transfusion and also result from other infectious ways. There are pure HGV infection and superinfection with HBV and/or HCV in hepatitis G. Patients with pure HGV infection show no or slight symptoms. And HGV infection based on hepatitis B may result in chronic serious hepatitis. The distribution of HGV genotypes is probably region-specific.

关 键 词：病原学 庚型肝炎 RT-PCR HGV-RNA 

分 类 号：R512.630.2[医药卫生—内科学]