养心益肝汤对缺血性中风后遗症期患者血浆TXB_2、6-keto-PGF_(1α)含量的影响  

Effect of Yangxinyigan Decoction on the Content of TXB_2 and 6-keto-PGF_(1α) in Blood Plasma of Patients with Ischemic Apoplexy Sequelae

作　　者：王文兰 付彩文 

机构地区：[1]河北省涉县中医院,涉县056400 [2]河北省涉县医院,涉县056400

出　　处：《中国中医急症》2008年第7期895-897,共3页Journal of Emergency in Traditional Chinese Medicine

基　　金：河北省中医药管理局科研项目(No2007206)

摘　　要：目的观察养心益肝汤对缺血性中风后遗症期患者血浆TXB2、6-keto-PGF1α含量的影响。方法292例缺血性中风后遗症期患者随机分为治疗组154例(采用养心益肝汤和常规康复治疗)与对照组138例(采用常规康复疗法);比较两组患者神经功能缺损评分和血浆血栓素B2(TXB2)、6-酮-前列腺素F1α(6-keto-PGF1α)的变化情况。结果与治疗前比较,两组治疗后神经功能缺损评分明显降低,治疗组治疗后神经功能缺损评分明显低于对照组;两组治疗后血浆6-keto-PGF1α含量较治疗前显著升高,TXB2含量及TXB2/6-keto-PGF1α比值较治疗前显著降低;与对照组比较,治疗后治疗组血浆6-keto-PGF1α、TXB2含量和TXB2/6-keto-PGF1α比值均有显著性差异。结论养心益肝汤可提高缺血性中风后遗症期患者神经功能,其作用机制与调节6-keto-PGF1α和TXB2含量有关。Objective： To observe the effect of Yangxinyigan Decoction on the content of Thromboxan B2（TXB2） and 6-keto- Prostaglandin F1α（6- keto- PGF1α） in blood plasma of patients with ischemic apoplexy sequelae. Methods： 292 case of patients with ischemic apoplexy sequelae divided into two groups randomly, 154 cases of the treatment group was treated by Yangxinyigan Decoction. and routine tehabilitation, and 138 cases of the control group was treated by routine rehabilitation, to observe the neurologic impairment scores and the content of TXB2 and 6 - keto - PGF1α in blood plasma before and after treatment. Results： The neurologie impairment scores were deseened obviously in two groups. The neurologie impariment scores were decreased obviously in treatment groups. The content of 6 - keto - PGF1α in blood plasma were increased after treatment, and the content of TXB2, the ratio of TXB2 and 6 - keto - PGF1α were decreased obviously in two groups. The neurologic impairment scores, the content of TXB2,6 - keto - PGF1α, and the ratio of TXB2 and 6 - keto - PGF1α were different obviously in treatment groups. Conclusion： Yangxinyigan Decoction can improve neurologic function of patients with isehemic apoplexy sequelae through modulating the content of TXB2 and 6 - keto - PGF1α.

关 键 词：缺血性中风 血栓素B2 6-酮-前列腺素F1Α 神经功能缺损评分 养心益肝汤 

分 类 号：R255.2[医药卫生—中医内科学]