党参炔苷对胃溃疡模型大鼠胃黏膜损伤保护作用的研究  

Protective Effect of Lobetyolin on Gastric Mucosa of Experimental Gastric Ulcer in Rats

作　　者：宋丹[1] 王峥涛[1] 李隆云[2] 钟国跃[2] 

机构地区：[1]上海中医药大学中药研究所,上海201203 [2]重庆市中药研究院,重庆400065

出　　处：《中国中医急症》2008年第7期963-964,986,共3页Journal of Emergency in Traditional Chinese Medicine

基　　金：国家科技支撑项目(No2006BAI06A11-09)

摘　　要：目的通过乙醇致大鼠胃溃疡模型,探讨党参炔苷对胃黏膜的保护作用。方法制备乙醇致大鼠胃溃疡模型,观察党参炔苷对该模型治疗后大鼠溃疡指数的影响。放免法检测血清中胃泌素及血浆中前列腺素含量,酶联免疫法测血清中表皮生长因子含量。结果党参炔苷小剂量组溃疡指数明显低于模型组;党参炔苷小剂量组胃泌素含量明显低于模型组,前列腺素含量明显高于模型组,表皮生长因子含量有一定程度的增高。结论预先给大鼠以党参炔苷灌胃给药,对防止乙醇引起的胃黏膜损伤有一定的作用,党参炔苷抗胃黏膜急性损伤的机制之一可能为提高前列腺素的含量,从而对抗胃泌素的泌酸作用,刺激胃黏膜合成释放表皮生长因子。Objective： To study the protective effect of lobetyolin on gastric mucosa of experimental gastric ulcer induced by ethanol in rats. Methods： The gastric ulcer model was established in rats by inducing ethanol. The index of ulcer was measured; the levels of Gas and 6 - K - PGF1α were examined by the method of radioimmunity; the level of EGF was measured by ELISA. Results： As compared with model group, in lobetyolin small dose group, the index of ulcer was markedly decreased, the level of Gas was decreased while the level of 6 - K - PGF1α was increased. In the degree, the level of EGF was increased. Conclusion： Lobetyolin has a protective role in gastric mucosa injury, and the mechanism may be relate to the increase in level of 6 - K - PGF1α and the inhibition the excretion of gastric acid and EGF.

关 键 词：胃溃疡 胃黏膜损伤 党参炔苷 胃泌素 前列腺素 表皮生长因子 

分 类 号：R285.5[医药卫生—中药学]