Palomo和改良Palomo曲张精索内静脉结扎术对大鼠同侧睾丸的影响  

The effects of Palomo and modified Palomo varicocelectomy on the ipsilateral testes in rats

作　　者：张孝斌[1] 郑轶群[1] 程帆[1] 周江桥[1] 周本正[1] 

机构地区：[1]武汉大学人民医院泌尿外科,430060

出　　处：《中华实验外科杂志》2008年第7期938-939,共2页Chinese Journal of Experimental Surgery

摘　　要：目的评估Palomo曲张精索内静脉结扎术（PV）和改良Palomo曲张精索内静脉结扎术（MPV）对大鼠同侧睾丸的影响。方法检测实验性左侧精索静脉曲张（ELV）组（9只）、PV组（10只）、MPV组（8只）、和对照组（8只）大鼠左侧睾丸的Johnsen’s评分、生精小管的超微结构、和生殖细胞凋亡指数（AI）。结果对照组Johnsen’s评分（9．46±0．52）显著高于ELV组（7．72±0．31，P〈0．05）和PV组（2．86±0．31，P〈0．01），与MPV组（9．42±0．63）比较差异无统计学意义（P〉0．05）；对照组AI（2．21±1．15）显著低于ELV组（5．32±1．23，P〈0．05）和PV组（9．26±1．98，P〈0．01），与MPV组（2．32±1．18）比较差异无统计学意义（P〉0．05）；ELY和PV组生精小管的超微结构明显异常。结论MPV可以修复ELV所导致的同侧睾丸的损伤，PV则使损伤进一步加重。Objective To investigate the effects of Palomo varicocelectomy （PV） and modified Palomo varieocelectomy （MPV） on the ipsilateral testes in rats. Methods The Johnsen＇ s score was recorded, ultrastrueture of seminiferous tubules observed, and germ cell apoptotie index （AI） detected in the left testes in the experimental left varieocele （ELV） group （n = 9 ）, PV group （ n = 10）, MPV group （n = 8） , and control group （ n = 8 ）. Results Johnsen＇ s score in control group （9.46± 0.52） was significant- ly higher than that in ELV group （7.72 ±0.31,P〈0.05） and PV group （2.86 v0.31,P 〈0.01） ,but there was no statistically significant difference between control group and MPV group （9.42 ± 0.63, P 〉 0.05）. Germ cell AI in control group （2.21 ± 1. 15） was significantly lower than that in ELV group （5.32 ± 1.23 ,P 〈 0.05 ） and PV group （ 9.26 ± 1.98, P 〈 0.01 ）, but had no statistically significant difference from that in MPV group （2.21 ± 1.15, P 〉 0.05 ）. Ultrastruetural abnormalities of seminiferous tubules were observed in PV and ELV groups. Conclusion The MPV can repair the varieocele-indueed lesion on the ipsilateral testes, but the PV can aggravate the injury.

关 键 词：睾丸 精索静脉曲张 精索内静脉结扎术 脱噬作用 

分 类 号：R699[医药卫生—泌尿科学]