何首乌对衰老大鼠海马脑源性神经营养因子表达的影响  

Influence of Polygonum Multiflorum on the Hippocampus B DNF Expression of Senile Rats

作　　者：李怡秋[1] 谭红[1] 李芳芳[1] 马俊骥[1] 

机构地区：[1]河北省石家庄市疾病预防控制中心,050011

出　　处：《职业与健康》2008年第16期1640-1641,共2页Occupation and Health

摘　　要：目的探讨何首乌对衰老大鼠海马脑源性神经营养因子(BDNF)表达的影响。方法给大鼠注射大剂量D-半乳糖,制衰老模型,12d时加饮何首乌水煎剂。通过Western Blot方法观测大鼠海马BDNF含量的变化。结果与对照组比较,D-半乳糖组大鼠和加何首乌组大鼠海马proBDNF含量均降低。结论何首乌对D-半乳糖引起的记忆力下降有预防作用,但是何首乌不影响BDNF的表达量。[ Objective] To explore the influence of polygonum multiflorum on the hippocampus BDNF expression of senile rats. [ Methods] Rats were injected with D galactose, then given Polygonum Multiflorum liquid after 12d; Western Blot method was used to observe the changes of hippocampus BDNF content of the rats. [ Results] The contents of hippocampus BDNF among both the D galactose group and the polygonum multiflorum group were lower than that of the control. [ Conclusion ] Polygonum multiflorum can prevent the memory decrease induced by D galactose, but doesnt influence the BDNF expression level.

关 键 词：学习记忆 大鼠 D-半乳糖 衰老 脑源性神经营养因子 何首乌 

分 类 号：R285.5[医药卫生—中药学]