丁香挥发油与氮酮对双氯芬酸钠促透作用的比较研究  

Permeation Enhancing Effect of Flos Caryophylli Volatile Oil Versus Azone on Diclofenac Sodium

作　　者：黄冬[1] 吴铁[2] 林坚涛[2] 陈广斌[1] 

机构地区：[1]广东医学院附属医院药学部,湛江市524001 [2]广东医学院药理研究室,湛江市524023

出　　处：《中国药房》2008年第21期1623-1625,共3页China Pharmacy

摘　　要：目的:比较丁香挥发油与氮酮对双氯芬酸钠的促透作用。方法:在体外透皮吸收装置上,测定不同时间双氯芬酸钠的透过量,计算稳态流量和增渗倍数,并考察其储库效应。结果:丁香挥发油和氮酮均有促进双氯芬酸钠经皮渗透的作用,当二者合用时效果更显著。丁香挥发油与氮酮单用及合用时对双氯芬酸钠的储库效应均有显著的增强作用(P<0.05或P<0.01)。结论:丁香挥发油对双氯芬酸钠具有较强大的促透作用,可望开发成为一种透皮吸收促进剂。OBJECTIVE： To evaluate the permeation enhancing effect of Flos Caryophylli volatile oil versus azone on diclofenac sodium. METHODS： Percutaneous absorption experiment was performed on the apparatus of isolated skin, and the penetrated amounts of diclofenac sodium at different time were measured, then the steady - state flux and enhancing rate were calculated, and the deposit effect of diclofenac sodium was investigated.RESULTS： Flos Caryophylli volatile oil and azone all had promotion effect on percutaneous absorption of diclofenac sodium,especially when they used in combination.Used either in combination or alone, they all had remarkable enhancement property on deposit effect of diclofenac sodium（P〈 0.05 or P〈 0.01）. CONCLUSION： Flos Caryophylli volatile oil is expected to become a skin penetration enhancer for its relative powerful promotion effect.

关 键 词：丁香挥发油 氮酮 双氯芬酸钠 促透作用 

分 类 号：R285[医药卫生—中药学] R971.1[医药卫生—中医学]