中药治疗慢性肾功能衰竭的临床观察  

作　　者：彭伟成 郑东文[2] 周志贤[3] 唐爱当[2] 

机构地区：[1]东莞市麻涌医院,523000 [2]东莞市人民医院肾内科,523000 [3]东莞市人民医院中医科,523000

出　　处：《中国社区医师（医学专业）》2008年第14期118-119,共2页

摘　　要：目的:探讨中药合剂治疗慢性肾功能衰竭的临床疗效。方法:采用优质低脂低蛋白饮食,根据病情给予对症处理(包括降血压、抗感染、纠正酸中毒等),加用中药合剂肾衰I号,每次30ml,每日3次,疗程为2个月。观察其临床症状及作用机制。检查血、尿常规,24小时尿蛋白定量、24h尿肌酐、肝功能、血肌肝(Scr)、血尿素氮(BUN)、血清TNF-α、NO水平。结果:治疗前后临床症状积分比较,60例CRF患者治疗前临床症状积分为13.07±1.67,治疗后症状积分值为6.42±1.56,明显下降,与治疗前比较有显著性差异(P<0.05)。血清TNF-α、NO正常参考值分别为<100pg/ml、76.1±17.1μmol/L,60例CRF患者治疗前血清TNF-α、NO均明显高于正常值。患者Scr与TNF-α(r=0.658)、TNF-α与NO(r=0.757)呈正相关(P<0.01);Scr与NO无明显相关性(r=0.470,P>0.05)。结论:肾衰I号合剂有降低患者血肌酐、尿素氮、改善肾功能的作用。Objective：To investigate treatment effects of traditional Chinese medicine on chronic renal failure. Methods：The patients were treatment with Shenshuaiheji I besides high- quality lowprotein diet and symptomic .treatment （ lower blood pressure, anti infection and correction of acidosis ）, all patients took Shenshuaiheji Ⅰ 30ml three times a day for 2 months. Routine blood test, urine analysis ,24 -hour urine protein and urine ereatinine excretion, liver function test, serum ereatinine concentration, blood urea nitrogen,blood TNF- α,NO level were measured. Results： The impact of clinical symptoms was 13.07 ± 1.67 before treatment and it was 6. 42 ± 1. 56 after treatment, the difference was significant（ P 〈 0.05 ）. Blood TNF - α,NO level were higher than normal, serum creatinine concentration and blood TNF α were positively correlated, blood＇ TNF- α,NO level were positively correlated, serum creatinine concentration and Blood NO level were not correlated. Conclusion： Shenshuaiheji I can decrease serum creatinine concentration and blood urea nitrogen, it is effective in the treatment of renal function.

关 键 词：中药 肾功能衰竭 疗效 

分 类 号：R692.5[医药卫生—泌尿科学] R274.915.3[医药卫生—外科学]