鼻息肉上皮细胞的分化  

Differentiation of epithelial cells in nasal polyps

作　　者：林心强[1] 王挥戈[1] 杨丹娜[1] 张燕[1] 郑朝生[1] 

机构地区：[1]汕头大学医学院第一附属医院耳鼻咽喉-头颈外科,广东汕头515041

出　　处：《中国耳鼻咽喉颅底外科杂志》2008年第3期177-180,200,共5页Chinese Journal of Otorhinolaryngology-skull Base Surgery

基　　金：广东省医学科研基金课题(A1997321)

摘　　要：目的探讨鼻息肉上皮细胞的分化状态及其病理学意义。方法采用免疫组化染色法检测鼻息肉组(29例)和下鼻甲组(11例)上皮细胞CK14、CK18和CK13蛋白的表达。结果①鼻息肉组上皮细胞CK14阳性指数,CK18阳性指数,CK13区域性表达率均大于下鼻甲组(P<0.01)。②鼻息肉上皮下微腺体上皮细胞CK18高表达,并与鼻息肉上皮CK18阳性细胞呈连续渐变的显微解剖学关系。结论①鼻息肉上皮基底细胞具有多向分化潜能,可以分化为假复层纤毛柱状上皮、非角化复层鳞状上皮和间质腺上皮,形成鼻息肉上皮种类的多样性。②鼻息肉鳞状化生现象较为多见,这可能是鼻息肉合并内翻性乳头状瘤和鼻息肉上皮存在原位癌区的病理学基础。Objective To explore the differentiation of epithelial cells in nasal polyps and its pathologic significance. Methods The expression of protein CK14 , CK18 and CK13 in epithelial cells of nasal polyp and inferior turbinate was detected with immunohistochemical staining. In this study, 29 eases were included in nasal polyp group, while 11 in inferior turbinate group. Results ① Positive indexes of CK14 （39. 74± 10. 65）, CK18 （62. 12± 15. 15）, and local expression rate of CK13 （13/29） in the epithelial cells of the nasal polyp group were all prominently higher than those of the inferior turbinate group （12. 34±6. 86, 41. 73±8. 62, and 2/11 respectively） （ P〈0. 01）.② Subepithelial microglands in nasal polyps, with high CK18 protein expression, were associated with CK18-positive epithelial cells in a mierotopographie manner of continuous and gradual change. Conclusion ① Epithelial basal cells in nasal polyp, as stem cells, can differentiate into epithelia of various types, such as pseudomuhilayer cilia column epithelium, muhilayer squamous epithelium, and glandular epithelium in medium. ② Sqnamatization is common in epithelia of nasal polyps, which might be the pathologic foundation of development of local ＂ tumor in situ＂ as well as inverted papilloma in the epithelia of nasal polyp.

关 键 词：鼻息肉 上皮细胞 分化 

分 类 号：R765.25[医药卫生—耳鼻咽喉科]