公式法计算肾小球滤过率的有效性及应用  

A comparison of ten prediction equations for estimating glomerular filtration rate and the analyse of the incidence and risk factors of nephropathy in chinese people in nanjing

作　　者：任海滨[1] 邢昌赢[1] 廖静[2] 刘佳[1] 储腊萍[1] 于波[1] 庄凌[1] 

机构地区：[1]南京医科大学第一附属医院肾内科,210029 [2]南京医科大学第一附属医院体检科,210029

出　　处：《临床肾脏病杂志》2008年第6期264-267,共4页Journal Of Clinical Nephrology

摘　　要：目的以标准化内生肌酐清除率（sCcr）为标准，从肾小球滤过率（GFR）计算公式中选择最适合中国人的公式用于统计慢性肾脏病（CKD）的发病率，并分析其危险因素。方法对435例确诊为CKD1～4期的患者进行了统计，抽取其中117例患者用同位素法测定GFR和Ccr，比较两者的相关性；对余318例以GFR计算公式与sCcr的关系进行研究，从中选择一个最具相关性的公式。收集我院体检人群中的2026例样本，用上述相关性最好的公式计算各样本的GFR，统计肾病的发病率，并分析其危险因素。结果在所有样本组中，与sCcr最具相关性的公式是Cockcroft-Gault公式，相关系数为0．802。用此公式计算体检人群的GFR，结合CKD病史、尿检和／或B超检查等，统计出中国南京地区肾病的发病率为7．502％。与CKD发病相关的主要因素有血肌酐水平高、年长、体重轻、女性、身材矮和血清甘油三酯高等。结论计算GFR的Cockcroft-Gaul公式适合于多数中国人群，可以用来筛选CKD患者。Objective To find the best equation for estimating GFR for Chinese people from the prediction equations, and use this equation to analyze the incidence and risk factors of CKD in Chinese people. Methods There were 435 patients with CKD 1-4 satage and 2 026 well-being examingtian people enrolled. 117 of the patients were received^99m Tc-DTPA to get GFR. For the other 318 patients, their GFR were respectively calculated by using every equation. Then the correlation between GFR, sCcr and Ccr calculating from each equation were analyzed, so as to reach the best equation, which was used to calculate health checkup people＇ s GFR. Finally, the incidence and risk factors of CKD in Nanjing of Chinese well-being examingtian people were assessed. Results In all patients, the best correlative equation was Cockcroft-Gault equation. The R value was 0. 802. Using this equation to calculate the 2 026 well-being examingtian people＇s GFR, the incidence of CKD was 7. 502%, and factors associated were serum creatinine concentration, age, body weight, gender, body height, serum triglyceride concentration. Conclusions The best correlative equation for estimating GFR is Cockcroft- Gault equation for Chinese people. The incidence of CKD in Nanjing of Chinese well-being examingtian people is 7. 502%, and there have some risk factors involving CKD.

关 键 词：肾小球滤过率 内生肌酐清除率 慢性肾脏病 

分 类 号：R692[医药卫生—泌尿科学] R657.34[医药卫生—外科学]