运脾方不同剂量对脾虚大鼠耐力作用的研究  

Study on Effect of Yun-Pi Prescription in Different Doses on Endurance of Rats with Splenic Asthenia

作　　者：崔利萍[1] 孙远岭[1] 周纬[1] 奚政君[1] 杨珍[1] 

机构地区：[1]上海交通大学医学院附属新华医院,上海儿童医学中心,上海200127

出　　处：《浙江中医药大学学报》2008年第4期446-447,共2页Journal of Zhejiang Chinese Medical University

基　　金：国家中医药管理局课题(No:DZX016A)~~

摘　　要：[目的]观察运脾方不同剂量对脾虚大鼠的耐力作用,探索治疗儿童厌食症的有效方药运脾方临床治疗效果的作用机理。[方法]通过建立利血平致脾虚动物模型,设立正常组、模型组、阳性对照组(消食健儿糖浆组),运脾方大剂量组、中剂量组、小剂量组,测定大鼠体重变化、食量消耗,以及测定游泳时间观察其对大鼠耐力的影响。[结果]运脾方能使脾虚大鼠的食量和体重明显增加的同时,延长了脾虚大鼠的游泳时间。[结论]运脾方能够有效地抗疲劳及改善脾虚大鼠耐力,对脾虚大鼠有明显的治疗作用。[Objective] To observe the effects of Yun-Pi Prescription of different doss on endurance of rats with splenic asthenia and to explore the mechanism of Yun-pi Prescription in treatment of children apositia. [Methods] To set up the animal model of splenic asthenia with reserpine. Experimental rats were randomly divided into six groups：the control group,the model group,the positive control group. Xiao Shi Jian Er Syrup, and Yun-Pi Prescription treatment groups including high, middle and low dose. Changes of body weight,food intake and swimming time were measured to determine the endurance of rats. [Results] Yun-Pi Prescription could increase body weight and food intake,prolong the swimming time of splenic asthenia rats. [Conclusion] Yun-Pi Prescription could effectively counteract fatigue and improve endurance of rats with splenic asthenia and it is useful in treatment rats with splenic asthenia.

关 键 词：运脾方 厌食症 脾虚 游泳实验 儿童 动物实验 

分 类 号：R285.5[医药卫生—中药学]