基于主症动态变化的病毒性肺炎疗效评价方法研究  

Method research of effect evaluation in treatment of virus pneumonia based on dynamic change of main syndrome

作　　者：汪受传[1] 赵霞[1] 任现志[1] 杨燕[1] 艾军[1] 李瑞丽[1] 谢雁鸣[2] 白文静[2] 

机构地区：[1]南京中医药大学儿科研究所,南京210029 [2]中国中医科学院中医临床基础医学研究所,北京100700

出　　处：《中华中医药杂志》2008年第8期675-679,共5页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：“十五”国家科技攻关计划课题(No.2004BA716B03)

摘　　要：目的:建立新的能够同时反映治疗方案干预后的阶段疗效和终点疗效的病毒性肺炎疗效评价方法。方法:以多中心、区组随机、平行对照临床试验结果作生存分析,寻找主症疗效产生的"拐点",提出基于起效时间的主症评分方法和疗效分级评价方法。以新方法与传统基于终点主症变化评价方法对本次临床研究作疗效评价对照。结果:新方法与传统方法对本次临床研究疗效评价结果存在正相关关系。结论:本研究提出的基于主症动态变化的病毒性肺炎疗效评价方法,更能全面、准确、客观地反映不同方案治疗病毒性肺炎的疗效,能彰显中医药治疗优势,是一种值得推广应用的病毒性肺炎疗效评价方法。Objective： To establish a new effect evaluation method of TCM which can reflect the terminal and phase effect of therapy program on virus pneumonia. Methods： Survive-analysis based on the results of multi-cehter, block randomization, parallel control clinic test and dynamic change of main syndrome were searched. The effect of the clinic test were evaluated by both the new method of main syndrome score and effect degree based on change trends and the traditional method based on change of terminal main syndrome. Results： A new effect evaluation method was put forward based on dynamic change of main syndrome. There was a positive correlation between the results of the clinic test using the new evaluation method and the traditional method. Conclusion： It indicates that the new method of effect evaluation not only show the advantage of Chinese medicine but also can be accepted by academe and should be applied widely.

关 键 词：病毒性肺炎 主症动态变化 疗效评价方法 临床研究 

分 类 号：R259[医药卫生—中西医结合]