克山病患者血浆脑利钠肽水平测定与分析  

Measurement and analysis of blood plasma brain natriuretic peptide in Keshan disease patients

作　　者：朱建宏[1] 杨杰[2] 何新科[2] 陈平[2] 刘保民[1] 王香玲[1] 牛小麟[1] 

机构地区：[1]西安交通大学医学院第二附属医院检验科,710004 [2]陕西省地方病防治研究所克山病、大骨节病科

出　　处：《中国地方病学杂志》2008年第4期452-454,共3页Chinese Jouranl of Endemiology

基　　金：陕西省科技攻关项目（2006K13-G7）

摘　　要：目的探讨克山病患者血浆脑利钠肽（BNP）水平与左心室功能的关系和临床意义。方法应用彩色多普勒超声诊断仪和微粒子酶免疫分析法，测量70例克山病患者（慢型25例、潜在型45例）及30例病区健康志愿者血浆BNP和左心室舒张末期内径（LVEDD）、左心室射血分数（LVEF）。结果慢型克山病组、潜在型克山病组的血浆BNP水平[（444．61±102．31）、（87．21±23．15）ng／L]较病区对照组[（34．91±15．21）ng／L]明显升高（q值分别为39．74、5．82，P〈0．01），慢型克山病组明显高于潜在型克山病组（q=37．62，P〈0．01）；LVEDD〉60mm的克山病患者血浆BNP水平[（928．80±134．27）ng／L]较LVEDD 55～60mm、〈55mm组[（89．24±52．31）、（67．14±6．92）ng／L]明显升高（q值分别为44．30、48．16，P〈0．01）；LVEF〈35％克山病患者的血浆BNP水平[（1654．21±421．35）ng／L]较35％～50％组[（421．54±112.32）ng／L]和〉50％组[（81．21±72．85）ng／L]明显升高（q值分别为24．91、72．66，P〈0．01），35％～50％组明显高于〉50％组（q=11．84，P〈0．01）。结论血浆BNP水平对于克山病的诊断、分型、治疗指导、预后评估具有重要的价值。Objective To investigate the relationship and clinical significance of blood plasma brain natriuretic peptide （BNP） and Keshan Disease （KD）. Methods Seventy KD patients and 30 healthy volunteers in endemic area were investigated with Doppler Echocardiography for the measurement of left ventricular end-diastolic diameter（LVEDD） and left ventricular ejection fraction（LVEF）, and the plasma BNP levels were determined with microparticle enzyme immunoassay. Results The BNP levels in plasma in KD patients [（444.61 ± 102.31）, （87.21 ± 23.15）ng/L] were significantly higher than that of healthy volunteers [ （34.91± 15.21）ng/L],the differencesbeing statistical significant （q = 39.74,5.82,P 〈 0.01）. The BNP levels in chronic KD patients were higher than that of latent KD patients （q = 37.62,P 〈 0.01 ）. The plasma BNP levels in KD patients with LVEDD 〉 60 mm [（928.80 ± 134.27）ng/L] were significantly higher than those of patients with LVEDD 55 - 60 mm [（89.24 ± 52.31）ng/L] and LVEDD 〈 55 mm [（67.14 -± 6.92 ）ng/L],the differencesbeing statistical significant （q = 44.30,48.16, P 〈 0.01）, The plasma BNP levels in KD patients with LVEF 〈 35%[（1654.21± 421.35） ng/L] were significantly higher than those of patients with 35% - 50% [（421.54 ± 112.32）ng/Ll and 〉 50% [ （81.21 ± 72.85 ng/L）1, the differencesbeing statistical significant（q = 24.91,72.66, P 〈 0.01 ）, The BNP levels in LVEF 35% - 50% were higher than that of 〉 50%（q = 11.84,P 〈 0.01）. Conclusion The plasma BNP levels were important for the diagnosis, grouping, therapeutic effect and prognostic evaluation of KD.

关 键 词：克山病 利钠肽 脑 每搏输出量 

分 类 号：R686[医药卫生—骨科学]