饮食限制对大鼠学习和记忆能力的影响  

Effects of dietary restriction on learning and memory ability in rats

作　　者：胡志红[1] 杨东伟[1] 胡咏梅[1] 任爱红[1] 阎君宝[1] 

机构地区：[1]河南科技大学医学院生理学教研室,河南洛阳471003

出　　处：《山东大学学报（医学版）》2008年第7期654-656,共3页Journal of Shandong University:Health Sciences

基　　金：洛阳市科委立项资助项目(040519);河南科技大学人才科研基金资助项目(05-062)

摘　　要：目的研究饮食限制对大鼠学习、记忆能力影响的性别差异。方法SD雌、雄大鼠各40只,按性别随机分为100%进食组(对照组)、80%进食组(限制20%组)、60%进食组(限制40%组)、50%进食组(限制50%组)4组,喂养30 d。测量体重,通过Morris水迷宫检测雌、雄大鼠各组的学习、记忆能力。结果限制40%组、限制50%组大鼠体质量明显下降(P<0.05),雄性大鼠限制40%组和限制50%组的学习能力明显增强(P<0.05),但记忆保持能力无明显改变,而雌性各组大鼠的学习和记忆能力均无明显改变。结论饮食限制对学习记忆能力的影响与性别有关。Objective To explore sex-related effects of dietary restriction （DR） on learning and memory in rats. Methods Male and female rats were fed a standard rodent diet and hbitum （control）, 80% of control （20% DR）, 60% of control （40% DR）, or 50% of control （50% DR） for 30 days. Then, the ability of learning and memory of the male and female rats was measured by the Morris water maze. Results Body weight of the DR rats was reduced relative to the controls except that of the 20% DR group. Learning and memory retention test in the Morris maze demonstrated that 40% DR and 50% DR increased learning but not retention in male rats, whereas neither learning nor retention was affected in females. Conclusion DR produces sex-dependent effects on learning.

关 键 词：饮食限制 学习 记忆 性 大鼠 近交系 

分 类 号：R338.6[医药卫生—人体生理学]