脑神康对糖尿病大鼠脑内单胺类神经递质含量的影响  

Effect of the Naoshenkang on monoamine neurotransmitters in the brain tissue of diabetes mellitus rats

作　　者：耿磊[1] 刘德山[1] 郝媛媛[1] 郭瑞臣[1] 王新陆[2] 张维东[3] 

机构地区：[1]山东大学齐鲁医院门诊部,济南250012 [2]山东中医药大学,济南250011 [3]山东省医学科学院基础医学研究所,济南250062

出　　处：《山东大学学报（医学版）》2008年第7期689-692,共4页Journal of Shandong University:Health Sciences

基　　金：山东省科技攻关计划项目(032050116);山东省1020工程20人员专项资助项目

摘　　要：目的观察益气补肾中药对糖尿病大鼠脑内单胺类神经递质含量的影响。方法腹腔注射链脲佐菌素(STZ)建立糖尿病Wistar大鼠模型,随机分为模型对照组和脑神康组,健康大鼠为正常对照。脑神康组每日给予脑神康,按600 mg/kg灌胃,其他两组给予等量生理盐水灌胃,喂养6周后处死动物,采静脉血测血糖、胰岛素,取脑组织检测脑内单胺类神经递质含量。结果脑神康组的血糖、胰岛素水平均低于模型对照组(P均<0.05),大脑组织中的去甲肾上腺素(NE)、多巴胺(DA)显著降低,5-羟色胺(5-HT)显著升高,与糖尿病对照组比较差异均有统计学意义(P<0.05)。结论益气补肾中药能有效调节糖尿病大鼠脑内单胺类神经递质含量。Objective To explore the effect of the traditional Chinese medicine, Naoshenkang on monoamine neurotransmitters in brain tissues of diabetes mellitus rats. Methods The diabetic model of Wistar rats was duplicated with one streptozotocin intraperitoneal injection, and then the model were randomly divided into 2 groups： the model control group and the Naoshenkang-treatment group, and healthy rats served as the norrnal control group. The Naoshenkang-treatrnent group was lavaged with 600 mg/kg naoshenkang per day, and the model control and the normal control groups were given an equal dose of normal saline. On the sixth weekend, all rats were killed, and then levels of blood sugar and insulin were determined, also the monoamine neurotransmitters in the discrete brain areas were determined. Results The levels of blood sugar and insulin of the Naoshenkang-treatment group were significantly lower than those of the model group（ P 〈 0.05）, also the levels of norepinephrine （NE） and dopamine （DA） were decreased while the level of 5-hydroxytryptamine （5-HT） was significantly increased in the Naoshenkang-treatment group. The level of monoamine neurotransmitters was significantly different between the Naoshenkang-treatment group and the model group（ P 〈 0.05）. Conclusion The traditional Chinese medicine Naoshenkang can efficiently regulate the level of monoamine neurotransmitters in brain tissues of diabetes mellitus rats.

关 键 词：脑神康 糖尿病 单胺类神经递质 大鼠 近交系 

分 类 号：R587.1[医药卫生—内分泌] R977.15[医药卫生—内科学]