老年人载脂蛋白A5与血脂、脂蛋白及血糖的相关性  

Relationship between apolipoproteins A5 and lipids metabolism in elderly people

作　　者：孙秀芳[1] 陈焕芹[1] 李保应[1] 常静[1] 杨轶文[1] 邱蕾[1] 

机构地区：[1]山东大学齐鲁医院老年病科,济南250012

出　　处：《山东大学学报（医学版）》2008年第7期729-732,共4页Journal of Shandong University:Health Sciences

摘　　要：目的探讨老年人载脂蛋白A5(APOA5)与血脂、脂蛋白及血糖的相关性。方法应用AU1000/2700型自动生化分析仪对187例健康老年人进行血清总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、载脂蛋白A1(APOA1)、载脂蛋白B100(APO B100)和血糖(GLU)的检测。同时采用ELISA法测定血清APOA5。结果血清APOA5水平与血清TG水平之间呈显著负相关(P<0.01),与血清胆固醇(CH)、LDL-C、APOB100水平有负相关的趋势,与HDL-C、APOA1和GLU水平之间有正相关的趋势(P>0.05);APOA5水平女性低于男性(P>0.05)。结论①老年人血清APOA5水平与血清TG水平呈负相关,APOA5可能是TG代谢的重要调节因子之一;②性别对老年人血清APOA5水平无明显影响。Objective To investigate the relationship between apolipoproteins A5 and lipids metabolism in elderly people, Methotis The level of serum total cholesterol （TC）, triglyceride （TG）, high-density lipoprotein cholesterol （HDL-C）, low density lipoprotein cholesterol （LDL-C）, apolipoproteinA1 （APOA1）, apolipoproteinBl00 （APOB100） and glucose were determined in 187 elderly people, and APOA5 in 1 mL serum was determined under - 80 ℃ by the ELISA method, Results The APOA5 level was negatively correlated with plasma TG level （ P 〈 0.01 ） and had a positive tendency with the plasma HDL cholesterol, APOA1 and glucose levels and a negative tendency with TC, LDL cholesterol and APOB100 levels, but the difference was not significant （ P 〉 0.05）. The APOA5 level was higher in mean than in women, but the difference was ＇also not significant （ P 〉 0.05）. Conclusion The APOA5 level is negatively related to the plasma TC, level. APOA5 may be an important regulatory mechanism in TG metabolism.

关 键 词：载脂蛋白A-5 脂蛋白类 HDL胆固醇 脂蛋白类 LDL胆固醇 血糖 性 

分 类 号：R592[医药卫生—老年医学]