多发性肌炎/皮肌炎患者血清抗Jo-1和Mi-2等6种自身抗体检测的意义  

Correlation Study of Polymyositis/dermatomyositis and Jo-1,Mi-2,PM-SCL,PL-7,PL-12,Ro-52

作　　者：张健[1] 宋芹[1] 常虹[1] 李新建[1] 窦翠云[1] 李永哲[1] 张国勋[1] 

机构地区：[1]山东济宁医学院附属医院,272129

出　　处：《中国误诊学杂志》2008年第23期5548-5550,共3页Chinese Journal of Misdiagnostics

基　　金：2007济宁市科技立项项目[项目编号:济科发(2007)50]

摘　　要：目的:探讨多发性肌炎(PM)/皮肌炎(DM)患者血清中抗Jo-1,Mi-2,PL-7,PL-12肌炎特异性抗体(MSA)及抗PM-SCL,Ro-52肌炎相关性抗体(MAA)的临床意义。方法:选取36例确诊为PM/DM患者,利用欧蒙免疫印迹法检测其血清中这6种抗体,并计算出血清MSAs和MAAs的阳性率,分析患者的临床表现、疾病活动性及预后与自身抗体的相关性。结果:36例患者中22例出现MSAs和(或)MAAs阳性(61%),其中MSAs阳性率为40%,最常见的MSAs是抗Jo-1抗体(30%),MAAs的阳性率为28%,抗Ro-52抗体占18%,并且与抗Jo-1抗体高度相关。结论:MSAs和MAAs在PM/DM患者中阳性表达率较高,MSAs与PM/DM的临床表现、疾病活动性和预后相关。Objective：Purpose Determinate polymyositis （PM） dermatomyositis （DM） in the serum of patients with anti-Jo-1. Mi-2. PL-7. PL-12 polymyositis specific antibody （MSA） and anti-PM-SCL. Ro-52 myositis associated antibody （MAA）.the positive rate on its PM/DM in significance. Methods ：36 cases diagnosed as PM/DM patients with serum using oumeng immunoblotting test the serum of patients With anti-Jo-1.Mi-2.PM-SCL,PL-7,PL-12,Ro-52 antibody, and calculated serum MAAs MSAs and the positive rate of pauents with clinical manifestations, and prognosis of disease aeuvity and the associated autoantibodies. Results： 36 cases with 22 cases of MSAs and （or） MAAs positive （61% ）. which MSAs positive rate was 40 percent, the most common MSAs was the anti-Jo-1 antibody （30%）. MAAs the positive rate was 28 % ,Anti-Ro-52 antibody for 18 per cent,and with the anti-Jo-1 antibody highly relevant. Conclusion ：MSAs and MAAs in PM/DM patients with high posiuve rate.MSAs with PM/DM of clinical performance ,disease activity and prognosis.

关 键 词：多发性肌炎/免疫学/血液 皮肌炎/免疫学/血液 抗体 抗核/分析 人类 

分 类 号：R593.26[医药卫生—内科学] R685.2[医药卫生—临床医学]