稀土2-氨基-4,6-二甲基嘧啶配合物的合成、表征及其生物活性研究  

Study on synthesis,characterization and biological activity of rare earth complexes with 2-amino-4,6-dimethylpyrimidine

作　　者：沈智慧[1] 许东芳[1] 夏庆春[1] 杨自芳[1] 何其庄[1] 金贻君[1] 彭子飞[1] 

机构地区：[1]上海师范大学生命与环境科学学院,上海200234

出　　处：《应用化工》2008年第7期721-724,共4页Applied Chemical Industry

基　　金：国家自然科学基金资助项目(20671063);上海市科委纳米技术专项(0652nm046)

摘　　要：以稀土氯化物、2-氨基-4,6-二甲基嘧啶为原料,制备了一类新型稀土配合物,通过元素分析、红外光谱、紫外光谱等手段对其进行了表征,确定了该配合物的化学组成:RE2(ADMP)(H2O)2Cl3(RE=La3+,Sm3+,Y3+,Er3+,ADMP=2-氨基-4,6-二甲基嘧啶)。抗菌实验结果表明,稀土配合物对大肠杆菌、金黄色葡萄球菌有较强的抑制作用,抗菌谱广。用MTT法对配合物使癌细胞凋亡能力做了初步研究,证明其具有使癌细胞凋亡的效果。A series of new rare-earth complex was prepared by rare-earth oxide （ RE ： La^3 ＋ , Sm^3 ＋ , y^3 ＋ , Er^3 ＋ ） and 2-amino-4,6-dimethylpyr/midine. Their compositions were characterized by elemental analysis, FT-IR and UV-VIS. The compositions of the complexes were confirmed to be RE2 （ADMP）（H2O） 2 Cl3. The antibacterial activity testing shows that all the complexes exhibit antibacterial ability against escherichia coil,staphylococcus aureus. The antimicrobial spectrum of the complexes are broad. MTT was used to study the anticancer ability of the complexes,which indicates that the cancer cells were withered by the complexes.

关 键 词：配合物 抗菌 抗肿瘤 

分 类 号：O641.4[理学—物理化学] O614.33[理学—化学]