白细胞介素-6基因多态性与再生障碍性贫血的相关研究  

Study on interleukin-6 polymorphism in patients with aplastic Anemia.

作　　者：梁红[1] 孙明艳[1] 靳明华[1] 魏负和[1] 

机构地区：[1]哈尔滨市第一医院哈尔滨市血液病研究所,哈尔滨150010

出　　处：《中国优生与遗传杂志》2008年第7期17-18,共2页Chinese Journal of Birth Health & Heredity

摘　　要：目的探讨白细胞介素-6(IL-6)基因启动子区域-174G/C基因多态性与中国北方汉族人再生障碍性贫血(AA)的相关性。方法应用顺序特异性引物和聚合酶链反应(PCR-SSP)技术,检测了36例AA患者(再障组)和40例健康献血者(对照组)中IL-6基因位点的多态性变化。结果结果表明IL-6基因-174G/C多态性位点基因型频率和等位基因频率在两组人群中的分布差异有统计学意义(χ2=6.31,P<0.05),G等位基因携带者患AA的风险是C等位基因的3.74倍(OR=3.7405)。两组之间比较差异有显著性意义,提示该等位基因频率增高与AA相关。结论IL-6基因-174G/C多态性与AA的发病具有相关性,其中G等位基因可能是我国北方汉族人AA发病的遗传易感基因,携带G等位基因的个体可能通过促进IL-6的高度表达进而增加AA的发病风险。Objective ： To investigate the relationship between the IL - 6 gene polymorphism and Aplastic Anemia. Methods： The polymorphisms of IL- 6 gene were analyzed by sequence specific primers polymerase chain reaction （PCR -SSP） methods in 36 patients with ovary cancer and 40 healthy controls. Results： The IL -6 gene - 174G/C polymorphism was significantly different between patients group and control group （ P 〈 0. 05） . The relative risk of AA patients of G allele was 3. 704times of the C allele （ OR=3. 7405）. Conclusion： IL -6 gene - 174 G/C polymorphism was associated with AA , and C allele may be a risk factor for AA, in which the IL- 6 C allele carriers may have increase risk by enhancing the IL -6. IL -6 genotype allele were significantly related to patients with AA. and IL- 6 C allele genotype can have some function susceptibility to AA.

关 键 词：白细胞介素-6(IL-6) 再生障碍性贫血(AA) 基因多态性(Gene Typing Polymorphism) 

分 类 号：R556.5[医药卫生—血液循环系统疾病]