安特尔联合他莫昔芬治疗特发性少精子症的疗效观察  

Effectiveness of combing tamoxifen citrate and testosterone undecanoate treatment with idiopathic oligozoospermia.

作　　者：侯开波[1] 闫素文[1] 周敏[1] 肖玉红[1] 白雪[1] 

机构地区：[1]解放军第202医院全军优生优育计划生育技术研究所,辽宁沈阳110003

出　　处：《中国优生与遗传杂志》2008年第7期96-96,113,共2页Chinese Journal of Birth Health & Heredity

摘　　要：目的评估他莫昔芬和安特尔联合应用对男性特发性少精子症精液参数的影响。方法60名特发性少精子症患者随机分成3组,分别接受安特尔,他莫昔芬,安特尔联合他莫昔芬治疗3个月,取患者精液分别进行精子形态学分析,检测精子数量(密度),精子活力(a+b百分率)。结果治疗3个月后,安特尔联合他莫昔芬组精子的数量,活力及功能等明显提高,均显著优越于单一用药组。结论安特尔与他莫昔芬联合应用能够显著提高特发性少精子症患者精液主要参数,为临床上治疗特发性少精子症的不育患者提供了一种有效方法。Objective： To evaluate the effects of combing tamoxifen citrate and T undecanoate treatment on seminal parameters in men with idiopathic oligozoospermia. Methods：Sixty oligozoospermic men were included in the protocol. Patients were randomized to receive T undecanoate （40 mg two times per day）, tamoxifen citrate （10 mg two times per day）, or T undecanoate plus tamoxifen citrate. Resuhs：Tamoxifen citrate plus T undecanoate treatment produced a satisfactory improvement of sperm density, motility, and functional sperm fraction after 3 months. Conclusion ： These results indicate that the combination of tamoxifen citrate with T undecanoate not only improves significantly important seminal parameters but also compares favorably with the single treatments used. Therefore, this combination deserves a place as a first line of treatment in idiopathic oligozoospermia.

关 键 词：特发性少精子症 安特尔 他莫昔芬 

分 类 号：R698.2[医药卫生—泌尿科学]